8. Maintenance of arterial blood pressure Flashcards
Blood Pressure
Cardiac Output x Peripheral Resistance
Normal MAP for healthy young adult
Systolic/Diastolic 120/80 mmHg
MBP calculation
[(2 x diastolic) + systolic] divided by 3
Poiseuille’s Law
If you halve the radius, resistance increases 16 fold!
Decrease HR
autonomic = vagus
transmitter = ACh
receptor = Cholinergic muscarinic (M2)
Increase HR/SV
autonomic= Sympathetic
transmitter= Noradrenaline
receptor = Adrenergic β1
Constrict Arteriole smooth muscle
autonomic = sympathetic
transmitter = noradrenaline
receptor = Adrenergic α1
Dilate Bronchiole smooth muscle
autonomic = Sympathetic
transmitter= Adrenaline
receptor= Adrenergic β2
Baroreceptor Location:
- Carotid sinus
- Aortic arch
Baroreflex response to a fall in MAP
SVR ↑
Venoconstriction
LV preload ↑
Inotropy ↑
HR ↑
MAP is restored
How is the baroreflex assessed experimentally?
Neck suction