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Infection > 8 Hepatisis > Flashcards

8 Hepatisis Flashcards

1
Q

What is hepatitis?

A

Inflammation of the Liver

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2
Q

What does prothrombin time measure?

A

How long blood takes to clot - extrinsic pathway

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3
Q

What makes a virus a hepatitis virus?

A

Replication in hepatocytes

Causes direct destruction of hepatocytes

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4
Q

What genome does HepB have?

A

dsDNA

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5
Q

What genome does HepC have?

A

ssRNA

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6
Q

What is jaundice?

A

High levels of bilirubin

Yellow skin

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7
Q

Where is haem broken down?

A

Broken down in spleen by RES

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8
Q

What reaction does it have to undergo to be excreted to the urine?

A

Conjugation

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9
Q

What are the three types of jaundice?

A

Pre-hepatic
Intra-hepatic
Extra-hepatic

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10
Q

What is the major cause of pre-hepatic?

A

Haemolysis

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11
Q

What is the major cause of intrahepatic?

A

Disease to the parenchymal cells

  • vira hep
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12
Q

What is the main cause of extrahepatic?

A

Obstruction of the billary passage

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13
Q

What test indicates hepatocyte damage?

A

Alanine transaminase levels

and AST

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14
Q

Why is PT an indication of liver function?

A

Clotting factors are made in the liver?

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15
Q

What does PT measure?

A

extrinsic pathway

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16
Q

How do you distinguish between haemolysis and cholestatis?

A

Haemolysis has a raised haemolgobin level

17
Q

What is the commonest transmission of HepB?

A

Vetical transmission

18
Q

What are the symotoms of HepB infection?

A 
Jaundice 
Fatigue 
Abdominal pain 
Anorexia/Nausea/Vomiting
Arthralgia
19
Q

What sort of person is acute Hep B infection most likely to become chronic?

A

Becomes chronic in 90% of people who are infected in childhood

20
Q

What are the 3 antigens seen in HepB infection?

A

Surface antigen
E-antigen
Core antigen

21
Q

Presence of what antigen says the disease is highly contagious?

A

E antigen

22
Q

What is the first detectable antigen in the body?

A

Surface antigen

23
Q

What is the definition of Hep B infection?

A

Persistence of HBsAg for 6 months

24
Q

What can Chronic hep b lead to

A

Cirrhosis and hepatocellular carcinoma

25
Q

How is chronic hep infection treated?

A

Life long anti-virals

26
Q

Draw out that antibody table

A

Now

27
Q

What is the blood test for HepC?

A

Looking for anti-Hep C antibody, shows if have had the infection, will test postive for life

VIral CPR confirms if is ongoing

28
Q

How is HepC treated?

A

Can be cured

Antiviral drug combo

29
Q

Draw out that table

A

…

Infection (13 decks)

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