7T: COTW

Question 1

How does Folic acid effect spina bifida?

Answer 1

• Folic Acid (Vitamin B9) is used in the body as THF
• Used in methylation and AA synthesis
• During development, post translational methylation of the cytoskeleton is required in neural cells for the closure of the neural tube

Question 2

What is Spina Bifida?

Answer 2

means “split spine”
Caused by failure of the caudal neural tube to close
there are three types:
a. Spina Bifida Occulta: no herniation
b. Meningocele: herniation of the meninges
c. Myelomeningocele: herniation of the meninges and spinal chord. Most sever form