77 Classification and Clinical Manifestations of Lymphocyte and Plasma

Question 1

Three major groups of lymphocyte and plasma cell disorders

Answer 1

Primary disorders
Acquired disorders
Neoplastic lymphocyte

Question 2

Delayed hypersensitivity normally is mediated by CD4 + helper T cells (Th cells) and, more specifically, _________ cells

Answer 2

Th1-type cells

Question 3

A deficit or functional disturbance in these cells can impair the cellular immune response to Mycobacteria spp, Listeria, Brucella, fungi, or other intracellular organisms associated with formation of immune granulomas

Answer 3

T Cells

Question 4

T helper subset that are suited to induce B-cell responses to antigen and direct the immune response against parasitic infestations.

Answer 4

Th2-type CD4 + Th cells

Question 5

Deficiency or defects in ____________cells can result in autoimmune disease

Answer 5

CD4 + regulator T cells

Question 6

Depletion or deficiency of __________ cells can result in impaired resistance to opportunistic infection

Answer 6

Th17 cells

Question 7

An extreme form of SCID

Children presenting early in life with severe infections, failure to thrive, and low-to-absent T cell and B cell numbers and function

Answer 7

T-cell–negative, B-cell–negative, NK-cell–positive phenotype

Question 8

Patients typically have neutropenia, anemia, vasculitic syndromes, fever of unknown origin, constitutional symptoms, cutaneous lesions, and autoimmune disorders, including rheumatoid arthritis, lupus erythematosus, Sjögren syndrome, and/or polymyalgia rheumatica.

Answer 8

Chronic NK cell lymphocytosis