73: Control of Blood Pressure and Volume Flashcards

1
Q

…… and ……… intake/excretion determines ECF, blood volume (BV) & blood pressure (BP)

A

Na+ and H20

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2
Q

When the body contains too much ECF, … and ……..rise

A

Blood Volume and Blood Pressure

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3
Q

Rise in urinary water (volume) excretion due to raised BP

A

Pressure diuresis

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4
Q

Rise in Na+ excretion due to raised BP

A

Pressure natriuresis

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5
Q

Autoregulation occurs when GFR and RBF constant with increases of BP between ……….

A

80-180 mmHg

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6
Q

Acute rise in blood pressure leads to intrinsic ………. in urinary Na+ excretion.

A

Increase Na+ Excretion.

no SNS, renin/angiotensin II, antidiuretic hormone activity (ADH

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7
Q

Chronic rise in Blood pressure leads to continued ……

A

Increase in urinary Na+ output due to hormonal activity (decrease R-A-A system; increase atrial natriuretic peptide (ANP)) excreting Na+/ H2O

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8
Q

……….. maintains fluid balance to keep changes in BV, ECF, CO & BP minimal even with large changes in Na+/ H2O intake

A

Feedback mechanism

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9
Q

If increase Na+/H2O intake, BP …………

A

Increases

To compensate renal output of Na+/H20 also increases.

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10
Q

If BP decreases, Na+/H2O intake …….

A

Decreases

To compensate renal output of Na+/H2O decreases

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11
Q

BV remains constant despite large changes in ………

A

Fluid Intake

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12
Q

Why does BV remains constant despite large changes in fluid intake?

A
  1. Slight change in BV changes cardiac output by changing mean circulatory filling pressure & venous return
  2. Change in CO changes BP
  3. Change in BP causes large change in urine output through pressure diuresis and hormonal activity
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13
Q

Only change seen in Blood Volume is when fluid intake is too………to make up for fluid losses (i.e. evaporation

A

Low

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14
Q

……… ,part of juxtaglomerulus apparatus, sense tubular flow of NaCl and send feedback signals to afferent or efferent arteriole to constrict/dilate to keep RPF and GFR at normal levels

A

Macula Densa Cells

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15
Q

The juxtaglomerular apparatus (JGA) responds to low blood volume or blood pressure (due to dehydration or loss of blood) stimulates the …………….system

A

Renin-Angiotensin-Aldosterone System

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16
Q

Protein enzyme released from granular cells of juxtaglomerular apparatus

A

Renin

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17
Q

The secretion of renin is stimulated by:

A
  1. Decreased arterial pressure leading to decreased renal perfusion pressure
  2. Decrease in NaCl sensed by macula densa cells
  3. Increased activity of renal sympathetic nerves
18
Q

Renin catalyzes conversion angiotensinogen to Angiotensin I eventually giving ………….

A

Angiotensin II

19
Q

Powerful controller of Na+ reabsorption

A

Angiotensin II

20
Q

Angiotensin II secretion is stimulated by…..

A
  1. Decreased arterial pressure leading to decreased renal perfusion pressure
  2. Low Na+ intake
21
Q

Actions of Angiotensin II:

A

Actions:
➢ Stimulates aldosterone secretion from adrenal glands ➢ Vasoconstriction (renal arterioles - mainly efferent when low; afferent when high)
➢ Stimulates thirst
➢ Increase NaCl reabsorption in proximal tubule
➢ Increases Na+/H+ exchanger in proximal tubule (therefore also aids in ??? reabsorption)

22
Q

Angiotensin II causes increased Na+/H20 reabsorption in the ……… which indirectly stimulates Na+ reabsorption in LD/CD via aldosterone.

A

Proximal Convoluted Tubule

23
Q

Angiotensin II ……… blood pressure via vasoconstriction and …….. the drive to drink

A

Increases blood pressure

Increases drive to drink

24
Q

Angiotensin II ……… Na+/H2O excretion, …………..ECF & arterial pressure

A

Decreases Na Na+/H2O excretion

Increase ECF & arterial pressure

25
Q

➢ Secreted by glomerulosa cells of adrenal cortex
➢ Binds to basolateral receptors on principals cells of LD/CD
➢ Directs synthesis of proteins involved in Na+ reabsorption (luminal membrane Na+ channel, Na+/K+-ATPase)

A

Aldosterone

26
Q

Aldosterone secretion is stimulated by:

A
  1. Angiotensin II
  2. Hyperkalemia (high plasma [K+])
  3. Hyponatremia (low plasma [Na+])
27
Q

Actions of Aldosterone:

A

Actions:
➢ Increase Na+/H2O reabsorption by principal cell in LD/CD
➢ Increase K+ secretion
➢ Increase H+ secretion from a-intercalated cells

28
Q

The overall effect of the Renin-Angiotensin-Aldosterone System:

A

Low blood pressure (BP) stimulates renin secretion from the kidney. Renin stimulates the production of Angiotensin II, which stimulates aldosterone secretion from the adrenal cortex. Aldosterone increase Na+ and water reabsorption in the kidney.

29
Q

Increases in ECF volume dilute OncoticPC and ……… PCT reabsorption

A

Decrease

30
Q

………. in ECF volume concentrates OncoticPC and stimulates PCT reabsorption

A

Decreases

31
Q

Nerves reduces Na+ excretion in 3 ways:

A
  1. Decreases GFR and RBF leads decreased filtered Na+ load and PT cap hydrostatic pressure for excretion
  2. Direct stimulatory effect on Na+ reabsorption by renal tubules
  3. Causes renin release leads to increases angiotensin II and aldosterone levels for reabsorption
32
Q
  • Peptide hormone secreted by posterior pituitary
  • Involved in the regulation of body water content
  • Also called vasopressin
A

Anti-Diuretic Hormone (ADH)

33
Q

The secretion of Anti-Diuretic Hormone (ADH) is stimulated by:

A
  1. Increased plasma osmolarity of 1 mOsm/L (most important physiologic stimulus)
  2. Hypovolemic loss of >8% ECF (MOST POTENT stimulus)
34
Q

Large volume changes evoke ADH secretion regardless of …………

A

Osmolarity/Tonicity

35
Q

Actions of Anti-Diuretic Hormone (ADH):

A

Allows formation of water channels in the late distal and collecting duct increasing reabsorption of water  increases urine osmolarity and decreases urine flow volume
➢ Increases H2O permeability (V2 receptors)
➢ Increases contraction of vascular smooth muscle (V1 receptors)

36
Q

Actions of……… on renal tubule :
➢ Increases H2O permeability
➢ Increases 2Cl-/Na+/K+ co-transporter effectiveness
➢ Increases urea permeability

A

Anti-Diuretic Hormone (ADH)

37
Q

➢ADH binds to ………receptor
➢……………. that increases cAMP
➢ Increases in cAMP cause the insertion of …………(H2O channels) to facilitate H2O reabsorption

A

V2
G-protein coupled receptors
Aquaporins

38
Q

➢ Released by cardiac atrial myocytes
➢ Receptors found in adrenal cortex, vascular endothelium, collecting duct, distal tubule but NOT proximal tubule AND several areas in brain (i.e. thirst center)

A

Atrial Natriuretic Peptide (ANP)

39
Q

The secretion of Atrial Natriuretic Peptide (ANP) is stimulated by:

A

Atrial stretch from excess BV (ECF)

40
Q

Actions of Atrial Natriuretic Peptide (ANP):

A

Actions:
➢ Vasodilation (afferent arterioles - also constricts efferent arterioles)
➢ Inhibits Na+ reabsorption at medullary CD
➢ Inhibits norepinephrine & angiotensin II induced vasoconstriction
➢ Inhibits renin and aldosterone secretion
➢ Inhibits ADH secretion
➢ Inhibits adenylate cyclase in target tissues