59: Respiratory Acid Base

Question 1

Acid

Answer 1

molecule that releases an H+ ions in

solution

Question 2

Base

Answer 2

molecule that accepts H+ in solution

Question 3

buffer

Answer 3

substance that will bind to to H+

ions reversibly

Question 4

What Buffer Systems Offer The Most Buffering Power?

Answer 4

Intracellular proteins
Bicarbonate
Plasma proteins
Inorganic phosphate

Question 5

In ECF, which buffer system is the most important?

Answer 5

Bicarbonate System

CO2 + H2O ↔ H2CO3 ↔ H+ + HCO3-

Question 6

pH change of 1

Answer 6

10X change in [H+]

Question 7

Normal plasma pH range

Answer 7

7.35 – 7.45

Question 8

Alkalosis

Answer 8

HCO3- : PCO2 ratio ↑

hyperexcitability, tetany

Question 9

Acidosis

Answer 9

HCO3- : PCO2 ratio ↓

hypoexcitability, CNS depression

Question 10

Plasma pH is a simple function of which ratios?

Answer 10

HCO3- : PCO2

Question 11

Why is it important to maintain normal pH?

Answer 11

Acidosis or Alkalosis

Affect tertiary structure and function of all proteins

Question 12

1st Line Of Defense Against pH Change

Answer 12

Buffering

Question 13

2nd Line Of Defense Against pH Change

Answer 13

Changes in ventilation

(increase) in alveolar ventilation

Question 14

3rd Line Of Defense Against pH Change

Answer 14

Changes in renal handling of H+ & HCO3-