65: Urinary System II (Histo) Flashcards
thick descending portion of loop of Henle
Proximal Straight Tubule
Where is the Proximal Straight Tubule found?
in the medullary ray of the cortex & also in outer medulla
Longer in juxtamedullary nephrons and are found in the medulla
Thin segment of Loop of Henlé
What type of epithelium is in the Thin segment of Loop of Henlé?
thin simple squamous in both ascending and descending limbs in short nephrons
Arteriole and venule rectae form loops parallel to the loop of Henlé (fenestrated capillaries)
Help maintain osmotic gradient in interstitium
Vasa Recta (Countercurrent exchange system)
Hypertonic interstitium
causes loss of water from the arterioles as they descend into medulla and gain water into the venules as they ascend to the corticomedullary
junction
Also called distal straight tubule
Thick ascending limb
Where is the Distal Straight Tubule found?
in the medullary ray of the cortex & also in outer medulla
Functions of Distal Straight Tubule
Transports ions from the lumen of the tubule to the interstitium via active transport
Reabsorbs: Ca2+, Mg 2+, Na+, & HCO3-
Secretes: K+, H+, NH4
Parathyroid regulated Ca2+ reabsorption
Relatively impermeable to H20
Highest Na+/K+ ATPase
activity
What type of epithelium is in the Distal convoluted tubule?
Simple cuboidal epithelium
Fewer and shorter microvilli however extensive basal folds
Apically placed nucleus
Distal convoluted tubule
Modified cells of the distal straight tubule
Located at vascular pole
Senses changes in Na+
concentration w/n lumen of the distal tubule
Macula densa
regulates blood pressure
Juxtaglomerular apparatus
Juxtaglomerular apparatus components
Macula densa
Extraglomerular mesangial cells
(Lacis / Polkissen cells)
Juxtaglomerular cells (JG cells): modified smooth muscle cells of afferent arteriole Produce renin ( cleaves angiotensinogen to angiotensin I)
potent vasoconstrictor
stimulates aldosterone secretion from adrenal cortex
angiotensin II
What does aldosterone stimulate?
reabsorption of Na+ and secretion of K+ by
connecting tubules and collecting ducts
Connecting tubules
Connect DCT to cortical collecting duct
Contain cells from DCT and CD (principal
cells)
Play important role in secretion of K+ into
lumen