7.1 Introduction to CNS [Yeye Edition] Flashcards
Principles of _________:
1. Nearly All drugs with CNS effects act on a specific receptors that modulates transmission
2. CNS DRUGS are among the most important tools for studying all aspects of CNS physiology
3. Unraveling the actions of drugs with known clinical efficacy led to the hypotheses regarding the mechanism of disease
Pharmacology of CNS Drugs
_____ is supported by Astrocytes
Neuron
It is electrically excitable cells that process and transmit information via an electrochemical process
Neuron
What are the Classification of Neurons
Function
Location
Neurotransmitter they release
It holds on to blood vessels, prevents excessive sodium, and not allo drugs to readily affect our nervous system
Astrocytes
Most abundant cell in the brain and play HOMEOSTATIC support roles
Astrocytes
It is highly branched dendritic trees
Dendrites
Carries the OUTPUT SIGNAL of a neuron from the soma
Axons
It is protected by Myelin formed cells
Axon
True or False:
Neurons have hundred of Dendrites but generally only one Axon
True
Makes contact with other neurons at specialized junctions called Synapses
Axon terminal
High concentration of voltage-gated sodium channels
Axon initial segment
Insulates axon of long-range projection
Myelin sheath
Axon: Inside - __________
Oligodendrocyte
Axon: Outside -_________
Schwann cells
True or False:
Synapses do NOT physically come into contact into another neuron
True
Cells that wrap around the axons of projection neurons in the CNS forming the myelin sheath
Oligodendrocytes
Performs a variety of essential functions in the CNS and are NONNEURONAL SUPPORT CELLS
Neuroglia
What are the 3 Neuroglia
- Astrocytes
- Oligodendrocytes
- Microglia
Supportive role; closely associated with neuronal synapses
Astrocytes
Removal and recycling of neurotransmitters after release
Astrocytes
Wrap around axons of projection
neurons forming the myelin sheath
Oligodendrocytes
Increases speed of signal propagation and
insulates axons
Oligodendrocytes
Specialized macrophages derived from
bone marrow that settle in the CNS
Microglia
Major Immune defense system
Microglia
Protective functional separation of the circulating blood from the extracellular fluid of the CNS
Blood Brain Barrier
True or False:
Drugs must either be HIGHLY hydrophobic or engage specific transport mechanisms to enter CNS
True
