70. Pathologic pigmentation caused by melanin, lipofuscin, and ceroid Flashcards
Melanin, lipofuscin and ceroid are grouped as…
Autochton pigments
Anhaemoglobinogenous pigments
Reaction of forming melanin
Tyrosin → Melanin
- Tyrosinase enzyme initiates malnin by oxidation
Stimulation by the hypophysis
Melanin
pigment:
produced by :
stored by:
regulates by :
pigment: brownish-black
produced by : melanocyte
stored by: melanophage
regulates by: hypophysis
Where in the body is melanin located (physiologically)
- Skin
- Epidermis & corium
- During prengnancy
- Nipples, face, mid-line of belly
- Eye
- Ganglion cells
- Leptomenings
- Oral cavity
- Mammary gland - Berkshire pigs
- Serous membrane - Reptiles & birds
Give the three variations of abnormal pigmentation
- Hyperpigmentatio
- Hypopigmentatio
- Albinismus
Lipofuscin
Pigment:
contain :
formed:
Pigment: Golden-brown
contain : Proteins & lipids, no iron
formed: lysosomes of ageing cells
Lipofuscin production
Autooxidation of unsaturated lipids
Lipofuscin: Location
- Liver
- Kidney tubule
- Adrenal gland
- Choroid plexus
- Muscle cells
Lipofuscin: Pathogenic conditions
- Brown bowel syndrome
- Neuronal ceroid lipofuscinosis
Ceroid
Pigment:
Produced in :
Pigment: yellow, Lipogenous
Produced in: macrophages and hepatocytes
Disease in Ceroid
Yellow fat disease: cause high amount of unsaturated fatty acid in the feed
Ceroid
found in:
- Lipocytes
- Macrophages
- MPS-cells
- Yellow adipose
