(7) Antimicrobials: Antivirals Hepatitis (7.1-7.2) Flashcards
Name 4 infectious agents interferon-α has been used to treat
(1) HHV-8 ⇒ Kaposi sarcoma
(2) HPV ⇒ Condyloma accuminata
(3) Hepatitis B
(4) Hepatitis C
Name 3 neoplasms interferon-α been used to treat
(1) Hairy cell leukemia
(2) Malignant melanoma
(3) Renal cell carcinoma
Adverse Effects (3) : Interferon-α
(1) Flu-like symptoms
(2) Myelosuppression
(3) Drug-induced lupus
Which interferon can be used to treat chronic granulomatous disease?
interferon-γ
Which interferon has been used to treat multiple sclerosis?
interferon-β
Prior to beginning treatment for Hepatitis C, what must be assessed?
Extent of liver fibrosis
Who is considered a candidate for treatment of Hepatitis C?
Everyone with virologic evidence of infection
(With the possible exception of those with limited life expectancy)
Define: Sustained virologic response
HCV RNA not detected by PCR for ≥ 6 mos. after treatment has stopped
What is/was the traditional treatment for Hepatitis C?
(1) Interferon-α
(2) Ribavirin
* (However, treatment is changing quickly with new protease and polymerase inhibitors)*
MOA: Ribavirin
Nucleoside analog
(Guanosine analog)
How is Ribavirin activated once in the cell?
Phosphorylation x3
(Nucleoside ⇒ Nucleotide)
Adverse Effects (2) : Ribavirin
(1) Hemolytic anemia
(2) Teratogen
* (Hemolytic anemia is dose-dependent)*
Name 2 infections that Ribavirin has been used to treat
(1) Hepatitis C
(2) Respiratory syncytial virus
* (RSV treatment now typically involves Palivizumab instead)*
MOA: Sofosbuvir
Nucleoside analog
(⇒ Inhibition of NS5B RNA production)
Adverse Effects (2) : Sofosbuvir
(1) Fatigue
(2) Nausea
