6.18 - Cardiovascular Disorders Flashcards
What is the definition of heart failure?
Heart unable to maintain adequate circulation for metabolic requirements of body
What is systolic heart failure?
- reduced ejection fraction (HFrEF) where EF > 40% but reduced systolic function
- left ventricle has weakened heart muscle and muscle is more dilated so less able to pump blood out of it thus reduced EF
What is diastolic heart failure?
- preserved ejection fraction (HFpEF) where EF > 50% and reduced diastolic function
- stiff heart muscle in left ventricle means smaller area for blood in it so less blood fills ventricle - but still get reasonable amount pumped out which is why EF is preserved
- so you get ventricular hypertrophy
What is the main ECG finding of heart failure?
Bigger QRS complex due to increased muscle mass in heart so more electrical current - not always found in heart failure
What are some underlying causes of heart failure?
- secondary to cardiac damage (ischaemia, myopathy)
- hypertension
- valve disease
What are the signs and symptoms of heart failure?
Exertional dyspnoea (i.e. breathlessness during exertion)
What are the tests for heart failure?
- blood test - elevated brain natriuretic peptide (BNP)
- chest X-ray - cardiomegaly
What are the treatment options for heart failure?
Drugs that reduce the exertional pressure on the heart
What is atrial fibrillation? (Electrical transmission disorders - atrial arrhythmias)
- disorganised electric activity and contraction due to pacemaker cells forming in regions outside of SAN and AVN
- prevents smooth transition of electrical current from SAN to AVN
- caused by spontaneously active cells throughout the atria
What are the ECG findings for atrial fibrillation?
Absent P-waves and ‘irregularly irregular’ rhythm
How is atrial fibrillation treated?
Strategies to maintain sinus rhythm (e.g. cardioversion, anti-arrhythmics, catheter ablation)
What is Wolff-Parkinson-White (WPW)? (Electrical transmission disorders - atrial arrhythmias)
- syndrome causing tachycardia and abnormal cardiac electrical conductance
- caused by additional accessory conduction pathway (the bundle of Kent) between the atria and ventricles
What are the ECG findings for Wolff-Parkinson-White?
- QRS pre-excitation
- biphasic/inverted T-wave of ECG - caused by current not being stopped at AVN and another depolarisation starting when ventricles are still repolarising
What are the treatment options for Wolff-Parkinson-White?
Benign - no treatment required
What are the signs and symptoms of atrial fibrillation and Wolff-Parkinson-White? (Atrial arrhythmias - electrical transmission disorders)
Palpitations and chest pain
What is a first-degree block? (Conduction block - electrical transmission disorders)
Slowing down of conduction through AV node (like a traffic jam where current cannot pass through AVN from atria to ventricles as well)
What is the ECG like for a first-degree block?
Increased P-R interval
What is a second-degree block? (Conduction block - electrical transmission disorders)
Reduced transmission of signal from atria to ventricles (types I, II, III)
What is the ECG like for a second-degree block?
Increased P-R interval or ‘missing’ QRS complexes, depending on type of block
What is a third-degree block? (Conduction block - electrical transmission disorders)
- complete block of current from atria to ventricles
- medical emergency - no ventricular depolarisation and muscle contraction
What is the ECG finding for a third-degree block?
P-waves not followed by QRS complexes
What is the underlying cause of conduction block?
Damage (fibrosis, calcification, necrosis) to the conduction system (AV node or His-Purkinje system)
What are the treatment options for conduction block?
- discontinuation of AV-blocking drugs (e.g. beta-blockers, calcium channel blockers)
- pacemaker implantation in severe cases
What is hypertension? (Vasculature disorders)
Clinical BP > 140/90 mmHg & ambulatory BP daytime average > 135/85 mmHg for prolonged period
What does hypertension increase the risk of?
- stroke
- MI & heart failure
- kidney disease
- these can also turn around and increase risk of hypertension = vicious circle
What are the underlying causes of hypertension?
- primary (essential) - unknown
- secondary - resulting from another medical condition e.g. kidney disease, adrenal disease
What investigations can be done into hypertension?
Blood pressure measurement: readings > 135/85 mmHg
What are the treatment options for hypertension?
Lifestyle changes followed by anti-hypertensive medication
What are the types of acute coronary syndromes?
- Angina - chest pain due to myocardial ischaemia caused by atherosclerosis (two types - stable and unstable)
- Non-ST-elevated myocardial infarction (NSTEMI) - myocardial tissue damage due to prolonged ischaemia caused by atherosclerosis and artery blockage, coronary artery partially occluded
- ST-elevated myocardial infarction (STEMI) - serious myocardial tissue damage due to prolonged ischaemia caused by severe atherosclerosis and complete artery blockage
What are the signs and symptoms of angina?
Chest pain on exertion (stable) or at rest (unstable)
What is the ECG finding for angina?
Not too likely to see changes
What is the treatment for angina?
Vasodilators
What is the underlying cause for angina?
Atherosclerosis lesions of the coronary artery causing ischaemia
What are the signs and symptoms of NSTEMI?
- chest pain
- sweating
- nausea
- vomiting
What are the ECG and blood test findings for NSTEMI?
- ST-depression/no changes
- high troponin levels
What are the treatment options for NSTEMI?
- coronary stents
- antiplatelets
- vasodilators
- anti-emetics
- oxygen
- pain-relief
What is the underlying cause of NSTEMI?
Artery blockage
What are the signs and symptoms of STEMI?
- radiating chest pain
- sweating
- nausea
- vomiting
What are the ECG and blood test findings for STEMI?
- ST-elevation with reciprocal ST-depression
- high troponin levels
What are the treatment options for STEMI?
- coronary stents
- antiplatelets
- vasodilators
- anti-emetics
- oxygen
- pain-relief
What is the underlying cause of STEMI?
Complete artery blockage