6: Synaptic transmission pt2

Question 1

What are the three main types of neurotransmitter

Answer 1

• Acetylcholine
• Glutamate
• GABA

Question 2

What are two main classes of receptor

Answer 2

• Ligand-gated ion channels (ionotropic receptors) “stimulus gated”
• G- protein coupled receptors (metabotropic receptors)

Question 3

What type of channel does an acetylcholine receptor have

Answer 3

Ligand -activated ion channels

Question 4

What type of potential does acetylcholine receptors generate

Answer 4

Excitatory post synaptic potentials -EPSPs

Question 5

How many subunits does acetylcholine receptors have?

Answer 5

5 subunits (pentamer)

Question 6

How many transmembrane domains does acetylcholine have?

Answer 6

4 transmembrain domains

Question 7

What ions are actylcholine receptors permeable to?

Answer 7

Na2+ and Ca2+

Question 8

What energy output does acetylcholine have?

Answer 8

Depolarises

Question 9

Give some examples of drugs that Acetylcholine are blocked by

Answer 9

• Bungarotoxin (snake toxin)
• TTX
• Curare (a plant toxin)

Question 10

What type of channel does glutamate have?

Answer 10

-Ligand gated ion channels

Question 11

What type of potential does glutamate generate?

Answer 11

Excitatory (EPSP)

Question 12

How many subunits are in a glutamate receptor have?

Answer 12

Tetramer (4)

Question 13

How many transmembrane domains does glutamate have?

Answer 13

Three transmembrane domains

Question 14

What ions are glutamate permeable to?

Answer 14

There are three types of glutamate receptors, each permeable to different ions

• Kainate -Na+
• AMPA -Na+, K+
• NMHA -Na+, K+, Ca2+

Question 15

What energy output does glutamate have?

Answer 15

Depolarises

Question 16

Give some examples of drugs that block glutamate receptors

Answer 16

• Mg2 blocks NMDA receptor

- PCP “stardust” also blocks NMDA receptor

Question 17

What type of channel does GABA-A have

Answer 17

Ligand gated ion channels

Question 18

What type of potential does GABA-A have?

Answer 18

Inhibitory _IPSPs

Question 19

How many subunits does GABA-A have?

Answer 19

Pentamer (5 subunits)

Question 20

How many transmembrane domains does GABA-A have?

Answer 20

four transmembrane domains

Question 21

What ion is GABA-A permeable t?

Answer 21

Cl-

Question 22

What energy output does GABA-A have?

Answer 22

Hyperpolarises

Question 23

Give an example of a drug/toxin which blocks the GABA-A receptor?

Answer 23

Picrotoxin (plant toxin)