10: Skeletal Muscle Neurophysiology 2

Question 1

Describe the sequence of events that initiate skeletal muscle contraction

Answer 1

slides

Question 2

How many subunits are there in a nicotinic acetylcholine receptor?

Answer 2

5 subunits

Question 3

How many transmembrane domains are there in the nicotinic Ach receptor?

Answer 3

Each subunit (5) has four transmembrane domain

Question 4

What are the 3 states that the nicotinic AchR can be in?

Answer 4

• Resting (gate closed)
• Activated (gate open)
• Desensitised (gate closed)

Question 5

Describe how the nicotinic AchR can change between states

Answer 5

Drawing diagram may be helpful

Question 6

Describe the process of the muscarinic acetylcholine receptor

Answer 6

slides

Question 7

What is the agonist for a nicotinic receptor?

Answer 7

Nicotine

Question 8

What is the antagonist for a nicotinic receptor?

Answer 8

• Tubocurarine

- Alpha-neurotoxins

Question 9

What is the agonist of a muscarinic receptor?

Answer 9

Muscarine

Question 10

What is the antagonist of a muscarinic receptor?

Answer 10

Atropine

Question 11

What causes the inhibition of acetylcholine esterase

Answer 11

• Endrophonium

- Pyridostigmine

Question 12

Draw out/explain the acetylcholine life cycle

Answer 12

slides

Question 13

Describes what occurs during Myasthenia gravis

Answer 13

slides

-Write in own words (paragraphs, not bullet points) and then compare with slides

Question 14

How does acetylcholine esterase help with myasthnia gravis

Answer 14

slides

again, write in own words