6- Serotonin

Question 1

5-HT Receptors

Answer 1

15 receptors in 7 classes

Question 2

5-HT1, 5 Family

Answer 2

A-F

Couples to Gi and Go
(inhibits cAMP)

Provides negative autoreceptor feedback

Can also activate GIRK (K efflux)

Question 3

5-HT2 Family

Answer 3

A-C

Excitatory
Short term response

Question 4

5-HT3 Family

Answer 4

Only receptor family that is an ion channel

Non-selective cation channel

Mainly Na entering

Question 5

5-HT 4,6,7 Family

Answer 5

Excitatory

Increases cAMP

Question 6

5-HT 5 Family

Answer 6

Inhibitory

Question 7

Drugs that act on 5-HT3 Receptor

Answer 7

Injection anesthetics
Local anesthetics
Opiod analgesics
Cannabionoids
Antipsychotics

Question 8

Drugs that act on 5-HT3 Receptor- Injection Anaesthetics

Answer 8

Pentobarbital

Propofol

Question 9

Drugs that act on 5-HT3 Receptor- Local Anaesthetics

Answer 9

Cocaine

Lidocaine

Question 10

Drugs that act on 5-HT3 Receptor-Opiod Analgesics

Answer 10

Morphine

Hydrophorphone

Question 11

Drugs that act on 5-HT3 Receptor-Cannabinoids

Answer 11

THC

Anandamide

Question 12

Drugs that act on 5-HT3 Receptor-Antipsychotics

Answer 12

Chloropromazine

Clozapine