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NEUR 4100 > 2- Receptors > Flashcards

2- Receptors Flashcards

1
Q

GPCR

A

7 TM domain peptide

GTP binding to a heteromeric G protein (α, beta, gamma)

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2
Q

Gs

A

Activate adenylyl cyclase

Increase cAMP production

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3
Q

Gi

A

Inhibit adenylyl cyclase

Decrease cAMP production

Beta/gamma subunits activate G protein couple inwardly rectifying (GIRK) channels

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4
Q

Gq

A

Activate PLC

PIP2—> IP3 ad DAG

Betta/gamma inihibit PIP2 sensitive ion channels such as the KCNQ potassium channel

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NEUR 4100 (11 decks)

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