4- GABA Flashcards
1
Q
Composition of GABA(A)R
A
5 subunit heteromer
Need at least one α and one beta to bind GABA- binds at α beta interface
To bind other ligands (i..e BDZ), also need gamma
Ion channel (influx of Cl)
2
Q
GABA(A)R Subunits
A
6 α
3 beta
3 gamma
(have more but those are the main ones)
3
Q
Conditions GABAergic Drugs Used to Treat
A
Anxiety
GAD
Insomnia
Epilepsy
4
Q
Treatment- Orthosteric Agonist
A
Not very useful (targets everywhere)
5
Q
Treatment- Orthosteric Antagonists
A
Not really used (targets everywhere)
6
Q
Treatment- Non-competitive Antagonist
A
Not really used
7
Q
Treatment- PAM
A
Yes
8
Q
Treatment-NAM
A
Not really
9
Q
Treatment-GABA Transaminase inhibitor
A
Yes
i..e valproic acid
