6. Neurocognitive Disorders Flashcards

1
Q

3 Categories of NCD in the DSM5

A
  1. Delirium
  2. Major NCD
  3. Mild NCD
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

DF: A deterioration of cognitive function, with little/no disturbance of consciousness or perception, loss of multiple seperable but overlapping abilities

A

Dementia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Dementia Subtypes:

A

Alzheimer’s (50%+)
Vascular Dementia (10%) or mixed Vascular AD (15%)
Lewy Body Dementia (15-20%)
Frontotemporal dementia (5%)
Other neurodegenerative conditions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Differentiation in types of Dementia

A

Cortical and Subcortical (and mixed)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Alzheimer’s and Frontotemporal Dementia are examples of:

A

Cortical Dementias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Vascular Dementia and Parkinson’s Dementia are examples of:

A

Subcortical Dementias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Four A’s of Cortical Dementias (Symptoms)

A

Amnesia - Memory decline
Aphasia - change in language function
Apraxia - Motor difficulties
Agnosia - Inability to recognise objects, faces

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Four D’s of Subcortical Dementias (Symptoms)

A

Dysmneisa - Mild memory problems
Dysexecutive syndrome - Executive dysfunction
Delay - Slow thinking and moving
Depletion - Reduced complexity of thought

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

DF: Disturbance in attention (reduced ability to direct, focus, sustain shift attention) and awareness (reduced orientation to the environment)

A

Delirium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Delirium is a direct physiological consequence of one or more of the 3:

A
  1. Substance intoxication or withdrawal
  2. Medication induced
  3. Other medical condition
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

DF: Significant cognitive decline from previous level of performance in one or more cognitive domains:

  1. Concern by individual or others
  2. Standardised testing or assessment
A

Major NCD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Most common form of Major NCD (60-80%)

A

Alzheimer’s disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Age of onset for Alzheimer’s is usually after ___, onset prior to age ___ extremely rare.

A

65;45

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

First symptoms of Alzheimer’s usually noticed

A

Memory problems

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Cause of Alzheimer’s: _____ form when protein pieces clump together between nerve cells

A

Amylpoid Plaques

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Functional and Structural changes associated with Alzheimer’s

A

Hypofunction, Atrophy of Medial Temporal lobes, Hippocampus, Parietal lobes etc.

17
Q

Cause of Alzheimer’s: _____ form when Tau proteins detach from microtubules in neurons and clump together

A

Neurofibrillary Tangles

18
Q

Methods of detecting structural brain changes associated with Alzheimer’s

A

CT, MRI

19
Q

Methods of detecting functional brain changes associated with Alzheimer’s

A

fMRI, PET

20
Q

Biological Treatments for Alzheimer’s Disease

A

Biological treatments - Medication like Cholinesterase inhibitors, antidepressants and antipsychotics

21
Q

Psychosocial Treatments for Alzheimer’s Diseass

A
  1. Cognitive rehabilitation and stimulation
  2. Behavioural management and environmental changes
22
Q

Second most common dementia (20%)

A

Vascular Dementia

23
Q

A focal portion for the brain is injured due to an episode of interrupted blood flow for an extended period

A

Cerebral Vascular Accident (Stroke)

24
Q

Risk factors for Cerebral Vascular Accident (Stroke)

A

Hypertension, hyperlipidaemia, diabetes, smoking

25
Q

Two broad subtypes of Cerebral Vascular Accident (Stroke)

A

Ischaemic - Blockage, Hemmorhagic - Bleed

26
Q

Injury to the brain from an outside force

A

Traumatic brain injury

27
Q

Types of Traumatic Brain Injury

A

Penetrating head injury vs Closed head injury

28
Q

Primary Mechanisms of closed TBI

A

Acceleration and/or Deceleration:
Bruising (coup/contracoup lesions), Diffuse Axonal Injury (Twisting/stretching of nerve fibres)

29
Q

Secondary Mechanisms of closed TBI

A

Edema (Swelling), Intracranial Hemmorhaging/Pressure, Ischemia (Blockage of bloodflow), Seizures

30
Q

Lasting effects of TBI are either ___ or ___, or a mix of both.

A

Focal; Diffuse

31
Q

Two syndromes often seen in severe TBI

A

Amnestic Syndromes, Frontal lobe/Dysexecutive Syndromes

32
Q

Why is TBI rehabilitation needed?

A

Quality of life, financial costs

33
Q

Period following TBI of loss/disruption of consciousness

A

Post-traumatic Amnesia (PTA)

34
Q

Severity of TBI is rated using:

A

Glasgow Coma Scale

35
Q

Glasgow Coma Scale severity ranges (3-15):
Mild ___-___
Moderate ___-___
Severe ___-___

A

13-15; 9-12; 3-8