6 - HETEROCYCLES Flashcards

1
Q

what is a heterocyclic compound?

A

molecules in which one or more rings contain at least one other atom than carbon
common atoms are O, N, S, P etc

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2
Q

what is the structure of pyridine?

A
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3
Q

what is the structure of pyrrole?

A
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4
Q

what is the structure of furan?

A
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5
Q

what is the structure of thiopene?

A
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6
Q

what is Huckel’s rule for aromaticity?

A

of pi electrons in ring=4n+2

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7
Q

why can the lone pairs of pyridine not be delocalised into the aromatic ring?

A

that is because the sp2 orbital is perpendicular to the orbitals of the ring
it can react with H+ though

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8
Q

why can pyrrole not react with weak acids?

A

the lone pair is part of the aromatic system, it’s going to be really hard to give it up

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9
Q

what is the difference between the pKa and the pKaH?

A

the pKaH is the pKa of the conjugate acid

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10
Q

what is an enamine vs an imine?

A

imine: C=N double bond
enamine: C=C double bond next to an N

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11
Q

primary vs secondary amines and the resulting product when reacting with a ketone?

A

a primary amine will react with a ketone to form an imine (resonance structure with enamine)
a secondary amine will react with ketone to give an enamine

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12
Q

why are imines favored over enamines?

A

C=N bond is stronger than C=C

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13
Q

mechanism of acid hydrolysis to make a ketone?

A
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14
Q

when might N alkylation occur?

A

when the alkyl halide is small

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15
Q

stork enamine synthesis method

A
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