23 - PEPTIDES Flashcards
what are the obstacles to RNA therapeutics
what is the orientation and stereocemistry
of amino acids
all have an L configuration
all S except cysteine
pKa of the amino and carboxyl groups of amino acids
what AAs are the main constituents of collagen
glycine
proline and hydroxyproline
hydroxyproline is made by in vivo oxidation of proline, which requires vitamin C
how is an aldol reaction catalysed by proline?
2021 nobel prise in chemistry
what groups need to be protected so that condensation of peptide synthesis happens as desired
one AA:
carboxy activated
amino protected
other AA:
carboxy protected
what are protecting groups for carboxylic acids
what are protecting groups for amines
how is fluorenemethyloxycarbonyl (Fmoc) removed?
what is the tert-butoxycarbonyl (t-Boc) group and how is it removed?
how does solid phase synthesis of a peptide happen?
mechanism of DCC reaction
condensing reagent required for the reaction
solid phase synthesis of nucleic acids, proteins and oligosaccharides and what needs to be controlled
what is the general strategy for the solid phase synthesis of oligosaccharides
