50. G6PD (Hemolytic Anemia)

Question 1

What is Glucose-6-phosphate dehydrogenase deficiency (G6PD)

Answer 1

Genetic disorder in point mutation that causes RBCs to break down prematurely
- it occurs more in men

Question 2

G6PD is associated with hemolytic anemia because…

Answer 2

RBCs are destroyed faster than they’re replaced

Question 3

s/s G6PD

Answer 3

• Pale skin
• Jaundice
• Dark-colored urine
• Fever, weakness, dizziness, confusion
• Trouble with physical activity
• Enlarged spleen and liver
• Increased HR, murmur

Question 4

What foods to avoid with G6PD

Answer 4

• Fava Beans!!! and all beans!
• moth balls (naphthalene)
• red wine
• blueberries
• soya
• tonic water
• camphor

Question 5

What meds to avoid with G6PD

Answer 5

d/t risk of hemolysis is dose-related:

• Aspirin
• Acetaminophen (Tylenol) is acceptable).
• Ascorbic acid (Vitamin C)
• Chloroquine
• Methylene blue
• Methyldopa (Aldomet)
• Sulfisoxazole (Pediazole)