28. Human Leukocyte Antigen (HLA)

Question 1

What is the HLA (HLA-B*58:01)

Answer 1

• Human Leukocyte Antigen on allele on allopurinol (Zyloprim)
• reduces immune response on cell surface

Question 2

HLA with allopurinol is strongly associated with _____, such as _____ and toxic _____

Answer 2

• severe cutaneous adverse reactions (SCAR)
• Steven-Johnson Syndrome
• epidermal necrolysis.

Question 3

_____ is used to reduce uric acid to treat gout and kidney stones.

Answer 3

Allopurinol (Zyloprim)

Question 4

HLA is most common in…

Answer 4

• korean
• han-chinese
• thai