5 (Student Presentation) - Anti tuberculosis: Cycloserine

Question 1

MoA of Cycloserine

Answer 1

Competitively inhibit two enzymes

1. L-alanine racemase: Forms D-alanine from L-alanine
2. D-alanylalanine synthetase: Incorporate D-alanine into the pentapeptide necessary for peptidoglycan formation and bacterial cell wall synthesis of Mycobacterium tuberculosis

Question 2

PK of Cycloserine

Answer 2

Absorption: 70-90% in GI tract

Distribution: Widely distributed in body tissues and fluids, including CSF

Metabolism: Liver (Primary)

Excretion: 70% excreted in urine

Question 3

Common side effects of Cycloserine

Answer 3

Psychosis, Dizziness, Vertigo, Headache, Sleep disturbances, Peripheral neuropathy, and Depression