2 (Student Presentation) - Classification of Antibiotics based on Spectrum of Activity

Question 1

3 types of antibiotic based on spectrum of activity

Answer 1

Narrow-spectrum, broad spectrum, and extended-spectrum

Question 2

Similarities and differences between narrow-spectrum, broad-spectrum, and extended-spectrum antibiotics

Answer 2

Narrow-spectrum: Either work only on Gram (+) or Gram (-) bacteria, more specificity (lower chance of bacterial resistance), less harm to microbiome

Broad-spectrum: Effective for wide range of Gram (+) & Gram (-) bacteria, higher chance of bacterial resistance, more harm to microbiome (superinfection)

Extended-spectrum: Active on inhibiting/killing Gram (+) and some Gram (-) bacteria, enhanced properties, more effective in gram (-) than gram (+), more resistant to inactivation by beta-lactamases, and more readily penetrate outer membranes

Question 3

Examples of narrow-spectrum antibiotics

Answer 3

Penicillin G, vancomycin, fidaxomicin, and sarecycline

Question 4

Example of broad-spectrum antibiotics

Answer 4

Racyclines and chloramphenicol

Question 5

E.g. extended spectrum antibiotics

Question 6

E.g. extended spectrum antibiotics

Answer 6

carbenicillin, mezlocillin, piperacillin