5 (Student Presentation) - Anti tuberculosis: Streptomycin

Question 1

MoA of Streptomycin

Answer 1

Binds to 16S rRNA and 12S protein on 30S bacterial ribosomes –> inhibit further ribosomal protein synthesis –> structural and functional change –> distortion of recognition site of anticodon and codon interaction –> misreading of message carried by mRNA –> cell death (bactericidal aminoglycoside)

Question 2

PK of Streptomycin

Answer 2

Absorption: Poorly absorbed in GIT; usually by IM or alternative choice in IV

Distribution: Vd 30-35% body weight

Metabolism: Usually not metabolized

Elimination: Primary route –> Urine (Glomerular filtration)

Question 3

Common side effects of Streptomycin

Answer 3

Allergic reactions, Ototoxicity & vestibular impairment, nephrotoxicity, and neurotoxicity

Question 4

Side effect management

Answer 4

Ototoxicity, vertigo, headache, and nystagmus –> stop taking streptomycin and change to ethambutol