5. Chikungunya

Question 1

• Positive sense
• single-stranded
• RNA

Answer 1

Chikungunya virus

Question 2

genus of Chikungunya

Answer 2

Flavivirus

Question 3

family of Chikungunya

Answer 3

Flaviviridae

Question 4

where Chikungunya is first recognized (in 1952) during an outbreak

Answer 4

Southern Tanzania

Question 5

“chikungunya” derives from a word in the
Kimakonde language of southern Tanzania, meaning ________

Answer 5

to become contorted

Question 6

Since 2004, outbreaks of CHIKV have become more frequent and widespread, caused partly due to ____

Answer 6

viral adaptations

Question 7

viral adaptations allowing the virus to be spread more easily by: (what mosquito?)

Answer 7

Aedes albopictus mosquitoes

Question 8

Chikungunya transmissions has been
____ on areas where a HIGH proportion of the population is infected then _____.

Answer 8

interrupted

immune

Question 9

Chikungunya cases in the Philippines

Answer 9

30

Question 10

Top 4 regions with Chikungunya cases:

Answer 10

1. DAVAO
2. Northern Mindanao
3. Ilocos
4. Western Visayas

Question 11

(2) Aedes mosquito of Chikungunya

Answer 11

1. A aegypti
2. A albopictus

Question 12

Chikungunya

Extrinsic incubation period: ____ days

Answer 12

7 - 12 days

Question 13

The transmission usually occurs during or just after the _______________.

Answer 13

hot rainy season

Question 14

In Africa, the virus is maintained in a
_____________ involving forest dwelling Aedes spp. mosquitoes and wild NHP

Answer 14

Sylvatic cycle

Question 15

Asia CHIKV have ____ transmission cycle

Answer 15

human-mosquito

Question 16

Other spp of CHIKV (3)

Answer 16

1, rodents
2. birds
3. small mammals

Question 17

Is there a vertical transmission to CHIKV?

Answer 17

YES

in women who developed the disease within the final week prior to delivery

Question 18

Typical sign of Chikungunya in humans?

Answer 18

arthralgia (joint pain)

Question 19

Acute phase of CHIKV lasts for ____ days.

Answer 19

10

Question 20

Chronic phase of the disease characterized by _______ ____ ____

Answer 20

recurrent joint pain

Question 21

Is there a lifelong immunity once recovered from chikungunya infection?

Answer 21

YES

Question 22

What is the BSL facility of CHIKV?

Answer 22

BSL 3

Question 23

Test for CHIKV (during the 1st week of illness)

Answer 23

RT-PCR in whole blood sample

Question 24

Serological test for CHIKV

• serum specimen from 4-5 days after the onset of illness
• cross-reactions between closely related alphaviruses

Answer 24

IgM antibodies

Question 25

Is there a vaccine for CHIKV?

Answer 25

NONE