5. Chikungunya Flashcards
- Positive sense
- single-stranded
- RNA
Chikungunya virus
genus of Chikungunya
Flavivirus
family of Chikungunya
Flaviviridae
where Chikungunya is first recognized (in 1952) during an outbreak
Southern Tanzania
“chikungunya” derives from a word in the
Kimakonde language of southern Tanzania, meaning ________
to become contorted
Since 2004, outbreaks of CHIKV have become more frequent and widespread, caused partly due to ____
viral adaptations
viral adaptations allowing the virus to be spread more easily by: (what mosquito?)
Aedes albopictus mosquitoes
Chikungunya transmissions has been
____ on areas where a HIGH proportion of the population is infected then _____.
interrupted
immune
Chikungunya cases in the Philippines
30
Top 4 regions with Chikungunya cases:
- DAVAO
- Northern Mindanao
- Ilocos
- Western Visayas
(2) Aedes mosquito of Chikungunya
- A aegypti
- A albopictus
Chikungunya
Extrinsic incubation period: ____ days
7 - 12 days
The transmission usually occurs during or just after the _______________.
hot rainy season
In Africa, the virus is maintained in a
_____________ involving forest dwelling Aedes spp. mosquitoes and wild NHP
Sylvatic cycle
Asia CHIKV have ____ transmission cycle
human-mosquito
Other spp of CHIKV (3)
1, rodents
2. birds
3. small mammals
Is there a vertical transmission to CHIKV?
YES
in women who developed the disease within the final week prior to delivery
Typical sign of Chikungunya in humans?
arthralgia (joint pain)
Acute phase of CHIKV lasts for ____ days.
10
Chronic phase of the disease characterized by _______ ____ ____
recurrent joint pain
Is there a lifelong immunity once recovered from chikungunya infection?
YES
What is the BSL facility of CHIKV?
BSL 3
Test for CHIKV (during the 1st week of illness)
RT-PCR in whole blood sample
Serological test for CHIKV
- serum specimen from 4-5 days after the onset of illness
- cross-reactions between closely related alphaviruses
IgM antibodies
Is there a vaccine for CHIKV?
NONE
