(4D) Caloric Restriction and Lifespan Flashcards
Which of these factors is LEAST likely to contribute to an increase in maximal length of life for animals on a calorically-restricted diet?
A. activation of AMPK
B. mitochondrial biogenesis
C. activation of sirtuins
D. activation of PGC-1α
E. activation of mTOR
E. activation of mTOR
Aging is related to a decrease in _____ gene expression
mitochondrial
The proposed mechanism for effects of caloric restriction involves _____ of AMPK and _____ of mitochondrial biogenesis via PGC-1alpha
activation; stimulation
Which increases maximal length of life in female mice?
A. insulin
B. IGF-1
C. leucine
D. resistance exercise
E. rapamycin
E. rapamycin
If you would like to increase the maximal length of life of your pet rats, mice, or dogs, what would be your best strategy
A. get them to do aerobic exercise
B. get them to do resistance exercise
C. activate their mTOR
D. restrict their caloric intake
E. all of the above
D. restrict their caloric intake
In monkeys, caloric restriction _____ survival rate and ______ age-related conditions
increases; decreases
If dogs are like rats, food restriction would _______ voluntary exercise.
A. decrease
B. increase
B. increase
In rats, caloric restriction increases
A. average length of life
B. maximal life span
C. both
C. both
Potential mediators of the effects of caloric restriction on maximal lifespan include all EXCEPT…
A. increased activation of mTOR
B. less stimulation of the insulin signaling pathway
C. activation of AMPK
D. increased expression of mitochondrial genes
A. increased activation of mTOR
In rats, exercise training increases…
A. average length of life
B. maximal life span
C. both
A. average length of life
the target of rapamycin (TOR) pathway is ____ by caloric restriction
inhibited
sirtuins ____ mitochondrial biogenesis
activates
AMPK _____ fat oxidation
increases
