4.3 Hematologic: Antiplatelet

Question 1

Irreversible COX inhibitor, instant prevention of arterial thrombosis

SE: tinnitus, hypersensitivity, reye syndrome

Answer 1

Aspirin

Question 2

ADP inhibitor, additive effects with aspirin

Answer 2

Clopidogrel, ticlopidine, prasugel

Question 3

Gp2b-3a inhibitor

Answer 3

Abciximab, eptifibatide

Question 4

Phosphodiesterase inhibitor, cardiac stress testing

Answer 4

Dipyridamole, cilostazol

Question 5

Triad of aspirin hypersensitivity

Answer 5

Samter triad

Asthma
Sensitivity
Nasal polyps

Question 6

ASA poisoning

Answer 6

CHAFS

Coma, hyperventilation, acidosis, fever, seizure

Question 7

Expected acid-base abnormality in salicylate poisoning

Answer 7

Respiratory alkalosis with HAGMA

Question 8

Difference between the presentation of aspirin intoxication in children and adults

Answer 8

Adults: mixed acid-base disorder, respiratory alkalosis with HAGMA

Children: pure acid-base disorder

Question 9

Difference between an inhibitor and an uncoupler of oxidative phosphorylation

Answer 9

Inhibitors: completely halt ETC

Uncouplers: dissipate proton gradient without interrupting ETC