3 Cardiovascular: Anti-hypertensive Flashcards
What is the formula for blood pressure?
Cardiac output X SVR
What is the expanded formula for blood pressure?
HR X SV X SVR
First line of drug for essential hypertension
JNC7 - HCTZ
JNC8- any but low dose
Hypertension with comirbid CHF/DM
SE: cough; angioedema
CI: bilateral RAS
Captopril
Used in ACE-inhibitor intolerance
Angiotensin receptor blocker (losartan)
Hypertension with comorbid BPH
Prazosin
Pre-eclampsia (maintenance medication)
SE: hemolytic anemia (positive coombs test)
Methyldopa
Pre-eclampsia (acute BP lowering)
SE: reflex tachycardia; drug-induced lupus
Hydralazine
Hypertensive emergency
SE: hypertrichosis
Minoxidil
Hypertensive emergency
SE: cyanide poisoning
Nitroprusside
Which part of the ETC is affected by cyanide?
Complex IV (cytochrome oxidase)
What is the antidote for cyanide poisoning?
Inhaled amyl nitrite
IV sodium nitrite
IV sodium thiosulfate