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Pharm U3 > 4) Antidepressants > Flashcards

4) Antidepressants Flashcards

1
Q

What is the class for Tranylcypromine (Parnate)

A

MAOI

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2
Q

What is the mechanism for Tranylcypromine (Parnate)

A

Irreversibly inhibit both MAOa and MAOb

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3
Q

What are the therapeutics for Tranylcypromine (Parnate)

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

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4
Q

What are the important side effects for Tranylcypromine (Parnate)

A

Hypertensive crisis (with tyramine-rich foods); serotonin syndrome (MAOI + SSRI); agitation (rare), delerium –> seizures

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5
Q

What are the other side effects for Tranylcypromine (Parnate)

A

Anticholinergic, orthostatic hypotension, sexual dysfunction, weight gain, sedation

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6
Q

What is the class for Phenelzine (Nardil)

A

MAOI

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7
Q

What is the mechanism for Phenelzine (Nardil)

A

Irreversibly inhibit both MAOa and MAOb

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8
Q

What are the therapeutics for Phenelzine (Nardil)

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

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9
Q

What are the important side effects for Phenelzine (Nardil)

A

Hypertensive crisis (with tyramine-rich foods); serotonin syndrome (MAOI + SSRI); agitation (rare), delerium –> seizures

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10
Q

What are the other side effects for Phenelzine (Nardil)

A

Anticholinergic, orthostatic hypotension, sexual dysfunction, weight gain, sedation

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11
Q

What is the class for Desipramine (Norpramin)

A

Tricyclic

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12
Q

What is the mechanism for Desipramine (Norpramin)

A

Block reuptake of NE or 5-HT at varying potencies and selectivity; also variably block muscarinic, a-adrenergic, dopamine, and histamine receptors

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13
Q

What are the therapeutics for Desipramine (Norpramin)

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

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14
Q

What are the important side effects for Desipramine (Norpramin)

A

Sympathomimetic (cardiac arrhythmias and conduction defects, especially at OD)

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15
Q

What are the other side effects for Desipramine (Norpramin)

A

Antimuscarinic, orthostatic hypotension, sedation (additive with alcohol), seizures

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16
Q

What are the miscellaneous for Desipramine (Norpramin)

A

Not very safe; rarely used anymore

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17
Q

What is the class for Imipramine (Tofranil)

A

Tricyclic

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18
Q

What is the mechanism for Imipramine (Tofranil)

A

Block reuptake of NE or 5-HT at varying potencies and selectivity; also variably block muscarinic, a-adrenergic, dopamine, and histamine receptors

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19
Q

What are the therapeutics for Imipramine (Tofranil)

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

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20
Q

What are the important side effects for Imipramine (Tofranil)

A

Sympathomimetic (cardiac arrhythmias and conduction defects, especially at OD)

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21
Q

What are the other side effects for Imipramine (Tofranil)

A

Antimuscarinic, orthostatic hypotension, sedation (additive with alcohol), seizures

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22
Q

What are the miscellaneous for Imipramine (Tofranil)

A

Not very safe; rarely used anymore; forms active metabolite (desipramine)

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23
Q

What is the class for Amitriptyline (Elavil)

A

Tricyclic

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24
Q

What is the mechanism for Amitriptyline (Elavil)

A

Block reuptake of NE or 5-HT at varying potencies and selectivity; also variably block muscarinic, a-adrenergic, dopamine, and histamine receptors

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25
Q

What are the therapeutics for Amitriptyline (Elavil)

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism; prevention of tension headaches, migraines

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26
Q

What are the important side effects for Amitriptyline (Elavil)

A

Sympathomimetic (cardiac arrhythmias and conduction defects, especially at OD)

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27
Q

What are the other side effects for Amitriptyline (Elavil)

A

Antimuscarinic, orthostatic hypotension, sedation (additive with alcohol), seizures

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28
Q

What are the miscellaneous for Amitriptyline (Elavil)

A

Not very safe; rarely used anymore; forms active metabolite (nortriptyline)

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29
Q

What is the class for Nortriptyline (Pamelor)

A

Tricyclic

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30
Q

What is the mechanism for Nortriptyline (Pamelor)

A

Block reuptake of NE or 5-HT at varying potencies and selectivity; also variably block muscarinic, a-adrenergic, dopamine, and histamine receptors

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31
Q

What are the therapeutics for Nortriptyline (Pamelor)

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

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32
Q

What are the important side effects for Nortriptyline (Pamelor)

A

Sympathomimetic (cardiac arrhythmias and conduction defects, especially at OD)

33
Q

What are the other side effects for Nortriptyline (Pamelor)

A

Antimuscarinic, orthostatic hypotension, sedation (additive with alcohol), seizures

34
Q

What are the miscellaneous for Nortriptyline (Pamelor)

A

Not very safe; rarely used anymore

35
Q

What is the class for Fluoxetine (Prozac)

36
Q

What is the mechanism for Fluoxetine (Prozac)

A

Inhibit reuptake of 5-HT (and NE to lesser extent)

37
Q

What are the therapeutics for Fluoxetine (Prozac)

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism; pre-menstrual dystrophic disorder

38
Q

What are the important side effects for Fluoxetine (Prozac)

A

Serotonin syndrom (with MAOIs)

39
Q

What are the other side effects for Fluoxetine (Prozac)

A

Fewer than tricyclics; mostly nausea, decreased sexual function

40
Q

What are the miscellaneous for Fluoxetine (Prozac)

A

Potent P450 inhibitor; forms active metabolite (norfluoxetine)

41
Q

What is the class for Paroxetine (Paxil)

42
Q

What is the mechanism for Paroxetine (Paxil)

A

Inhibit reuptake of 5-HT (and NE to lesser extent)

43
Q

What are the therapeutics for Paroxetine (Paxil)

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

44
Q

What are the important side effects for Paroxetine (Paxil)

A

Serotonin syndrom (with MAOIs)

45
Q

What are the other side effects for Paroxetine (Paxil)

A

Fewer than tricyclics; mostly nausea, decreased sexual function

46
Q

What are the miscellaneous for Paroxetine (Paxil)

A

Potent P450 inhibitor

47
Q

What is the class for Sertraline (Zoloft)

48
Q

What is the mechanism for Sertraline (Zoloft)

A

Inhibit reuptake of 5-HT (and NE to lesser extent)

49
Q

What are the therapeutics for Sertraline (Zoloft)

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

50
Q

What are the important side effects for Sertraline (Zoloft)

A

Serotonin syndrom (with MAOIs)

51
Q

What are the other side effects for Sertraline (Zoloft)

A

Fewer than tricyclics; mostly nausea, decreased sexual function

52
Q

What is the class for Escitalopram (Lexapro)

53
Q

What is the mechanism for Escitalopram (Lexapro)

A

Inhibit reuptake of 5-HT (and NE to lesser extent)

54
Q

What are the therapeutics for Escitalopram (Lexapro)

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

55
Q

What are the important side effects for Escitalopram (Lexapro)

A

Serotonin syndrom (with MAOIs)

56
Q

What are the other side effects for Escitalopram (Lexapro)

A

Fewer than tricyclics; mostly nausea, decreased sexual function

57
Q

What is the class for Citalopram (Celexa)

58
Q

What is the mechanism for Citalopram (Celexa)

A

Inhibit reuptake of 5-HT (and NE to lesser extent)

59
Q

What are the therapeutics for Citalopram (Celexa)

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

60
Q

What are the important side effects for Citalopram (Celexa)

A

Serotonin syndrom (with MAOIs)

61
Q

What are the other side effects for Citalopram (Celexa)

A

Fewer than tricyclics; mostly nausea, decreased sexual function

62
Q

What is the class for Duloxetine (Cymbalta)

63
Q

What is the mechanism for Duloxetine (Cymbalta)

A

Inhibits reuptake of 5-HT and NE

64
Q

What are the therapeutics for Duloxetine (Cymbalta)

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

65
Q

What is the class for Venlafaxine (Effexor)

66
Q

What is the mechanism for Venlafaxine (Effexor)

A

Inhibits reuptake of 5-HT and NE

67
Q

What are the therapeutics for Venlafaxine (Effexor)

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

68
Q

What is the class for Bupropion (Wellbutrin)

69
Q

What is the mechanism for Bupropion (Wellbutrin)

A

Blocks DA and NE reuptake

70
Q

What are the therapeutics for Bupropion (Wellbutrin)

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism; maintain nicotine abstinence in quitting smokers

71
Q

What are the important side effects for Bupropion (Wellbutrin)

A

Lowers seizure threshold

72
Q

What is the class for Mirtazapine (Remeron)

73
Q

What is the mechanism for Mirtazapine (Remeron)

A

5HT2a antagonists; also inhibit 5HT reuptake

74
Q

What are the therapeutics for Mirtazapine (Remeron)

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

75
Q

What is the mechanism for Lithium

A

Unknown; lithium depletes secondary messengers IP3 and DAG, important in a-adrenergic and muscarinic-cholinergic transmission

76
Q

What are the therapeutics for Lithium

A

Anti-manic/mood-stabilizing (bipolar); long-term cluster headache prevention

77
Q

What are the important side effects for Lithium

A

If elevated levels: neurotoxicity, cardiac toxicity, renal dysfunction

78
Q

What are the other side effects for Lithium

A

Drowsiness, weight gain, tremor, polydipsia, polyuria

79
Q

What are the miscellaneous for Lithium

A

Nausea and vomiting early sign of lithium OD; indomethacin and Na-depleting diuretics should be avoided (increase [Li])

Pharm U3 (13 decks)

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