13) Alzheimers Flashcards
What is the class for Tacrine (Cognex)
AChE inhibitor
What is the mechanism for Tacrine (Cognex)
Inhibits AChE and BuChE
What are the therapeutics for Tacrine (Cognex)
Mild to moderate Alzheimers
What are the important side effects for Tacrine (Cognex)
Transaminase elevation
What are the other side effects for Tacrine (Cognex)
Nausea, vomiting, diarrhea, abdominal cramping
What are the miscellaneous for Tacrine (Cognex)
Metabolized by P450; dosed 4/day; now obsolete
What is the class for Donepezil (Aricept)
AChE inhibitor
What is the mechanism for Donepezil (Aricept)
Inhibits AChE
What are the therapeutics for Donepezil (Aricept)
Mild to moderate Alzheimers; severe Alzheimers
What are the other side effects for Donepezil (Aricept)
Nausea, vomiting, sleep disturbance
What are the miscellaneous for Donepezil (Aricept)
Metabolized by P450; dosed 1/day
What is the class for Rivastigmine (Exelon)
AChE inhibitor
What is the mechanism for Rivastigmine (Exelon)
Inhibits AChE and BuChE
What are the therapeutics for Rivastigmine (Exelon)
Mild to moderate Alzheimers
What are the other side effects for Rivastigmine (Exelon)
Nausea, vomiting, sleep disturbance
What are the miscellaneous for Rivastigmine (Exelon)
Hydrolyzed by cholinesterases; dosed 2/day
What is the class for Galantamine (Razadyne)
AChE inhibitor
What is the mechanism for Galantamine (Razadyne)
Inhibits AChE; allosteric modulator of nicotinic receptors
What are the therapeutics for Galantamine (Razadyne)
Mild to moderate Alzheimers
What are the other side effects for Galantamine (Razadyne)
Nausea, vomiting, sleep disturbance
What are the miscellaneous for Galantamine (Razadyne)
Metabolized by P450; dosed 2/day (1/day for ER strength)
What is the mechanism for Memantine (Namenda)
Partial antagonist of NMDA receptor
What are the therapeutics for Memantine (Namenda)
Severe Alzheimers
What are the other side effects for Memantine (Namenda)
Dizziness, confusion, headache, constipation
What are the miscellaneous for Memantine (Namenda)
Excreted unchanged in urine; dosed 2/day