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Pharm U3 > 13) Alzheimers > Flashcards

13) Alzheimers Flashcards

1
Q

What is the class for Tacrine (Cognex)

A

AChE inhibitor

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2
Q

What is the mechanism for Tacrine (Cognex)

A

Inhibits AChE and BuChE

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3
Q

What are the therapeutics for Tacrine (Cognex)

A

Mild to moderate Alzheimers

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4
Q

What are the important side effects for Tacrine (Cognex)

A

Transaminase elevation

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5
Q

What are the other side effects for Tacrine (Cognex)

A

Nausea, vomiting, diarrhea, abdominal cramping

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6
Q

What are the miscellaneous for Tacrine (Cognex)

A

Metabolized by P450; dosed 4/day; now obsolete

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7
Q

What is the class for Donepezil (Aricept)

A

AChE inhibitor

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8
Q

What is the mechanism for Donepezil (Aricept)

A

Inhibits AChE

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9
Q

What are the therapeutics for Donepezil (Aricept)

A

Mild to moderate Alzheimers; severe Alzheimers

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10
Q

What are the other side effects for Donepezil (Aricept)

A

Nausea, vomiting, sleep disturbance

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11
Q

What are the miscellaneous for Donepezil (Aricept)

A

Metabolized by P450; dosed 1/day

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12
Q

What is the class for Rivastigmine (Exelon)

A

AChE inhibitor

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13
Q

What is the mechanism for Rivastigmine (Exelon)

A

Inhibits AChE and BuChE

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14
Q

What are the therapeutics for Rivastigmine (Exelon)

A

Mild to moderate Alzheimers

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15
Q

What are the other side effects for Rivastigmine (Exelon)

A

Nausea, vomiting, sleep disturbance

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16
Q

What are the miscellaneous for Rivastigmine (Exelon)

A

Hydrolyzed by cholinesterases; dosed 2/day

17
Q

What is the class for Galantamine (Razadyne)

A

AChE inhibitor

18
Q

What is the mechanism for Galantamine (Razadyne)

A

Inhibits AChE; allosteric modulator of nicotinic receptors

19
Q

What are the therapeutics for Galantamine (Razadyne)

A

Mild to moderate Alzheimers

20
Q

What are the other side effects for Galantamine (Razadyne)

A

Nausea, vomiting, sleep disturbance

21
Q

What are the miscellaneous for Galantamine (Razadyne)

A

Metabolized by P450; dosed 2/day (1/day for ER strength)

22
Q

What is the mechanism for Memantine (Namenda)

A

Partial antagonist of NMDA receptor

23
Q

What are the therapeutics for Memantine (Namenda)

A

Severe Alzheimers

24
Q

What are the other side effects for Memantine (Namenda)

A

Dizziness, confusion, headache, constipation

25
Q

What are the miscellaneous for Memantine (Namenda)

A

Excreted unchanged in urine; dosed 2/day

Pharm U3 (13 decks)

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