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Pharm U3 > 2) Neuroleptics > Flashcards

2) Neuroleptics Flashcards

1
Q

What is the class for Chlorpromazine (Thorazine)

A

First-generation antipsychotics (phenothiazine); Low Potency

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2
Q

What is the mechanism for Chlorpromazine (Thorazine)

A

Antagonize D2 receptors

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3
Q

What are the therapeutics for Chlorpromazine (Thorazine)

A

Schizophrenia (hallucinations, delusions)

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4
Q

What are the important side effects for Chlorpromazine (Thorazine)

A

NMS

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5
Q

What are the other side effects for Chlorpromazine (Thorazine)

A

Extrapyramidal, tardive dyskinesia; sedation, postural hypotension (alpha1 antag); weight gain and sedation (H1 antag); anticholinergic effects

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6
Q

What are the miscellaneous for Chlorpromazine (Thorazine)

A

Little effect on negative symptoms

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7
Q

What is the class for Fluphenazine (Prolixin)

A

First-generation antipsychotics (phenothiazine); High Potency

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8
Q

What is the mechanism for Fluphenazine (Prolixin)

A

Antagonize D2 receptors

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9
Q

What are the therapeutics for Fluphenazine (Prolixin)

A

Schizophrenia (hallucinations, delusions); movement disorder in Huntingtons

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10
Q

What are the important side effects for Fluphenazine (Prolixin)

A

NMS

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11
Q

What are the other side effects for Fluphenazine (Prolixin)

A

Extrapyramidal (more than chlorpromazine), tardive dyskinesia; sedation (less than chlorpromazine), hypotension; anticholinergic effects; sexual dysfunction

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12
Q

What are the miscellaneous for Fluphenazine (Prolixin)

A

Little effect on negative symptoms

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13
Q

What is the class for Trifluoperazine (Stelazine)

A

First-generation antipsychotics (phenothiazine)

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14
Q

What is the mechanism for Trifluoperazine (Stelazine)

A

ANtagonize D2 receptors

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15
Q

What are the therapeutics for Trifluoperazine (Stelazine)

A

Schizophrenia (hallucinations, delusions)

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16
Q

What are the important side effects for Trifluoperazine (Stelazine)

A

NMS

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17
Q

What are the other side effects for Trifluoperazine (Stelazine)

A

Extrapyramidal, tardive dyskinesia; sexual dysfunction, hyperprolactinemia

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18
Q

What are the miscellaneous for Trifluoperazine (Stelazine)

A

Little effect on negative symptoms

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19
Q

What is the class for Perphenazine (Trilafon)

A

First-generation antipsychotics (phenothiazine)

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20
Q

What is the mechanism for Perphenazine (Trilafon)

A

ANtagonize D2 receptors

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21
Q

What are the therapeutics for Perphenazine (Trilafon)

A

Schizophrenia (hallucinations, delusions)

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22
Q

What are the important side effects for Perphenazine (Trilafon)

A

NMS

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23
Q

What are the other side effects for Perphenazine (Trilafon)

A

Extrapyramidal (less than chlorpromazine), tardive dyskinesia; sedation (less than chlorpromazine); sexual dysfunction, hyperprolactinemia

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24
Q

What are the miscellaneous for Perphenazine (Trilafon)

A

Little effect on negative symptoms

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25
What is the class for Thioridazine (Mellaril)
First-generation antipsychotics (phenothiazine)
26
What is the mechanism for Thioridazine (Mellaril)
ANtagonize D2 receptors
27
What are the therapeutics for Thioridazine (Mellaril)
Schizophrenia (hallucinations, delusions)
28
What are the important side effects for Thioridazine (Mellaril)
NMS
29
What are the other side effects for Thioridazine (Mellaril)
Extrapyramidal, tardive dyskinesia; sexual dysfunction, hyperprolactinemia
30
What are the miscellaneous for Thioridazine (Mellaril)
Little effect on negative symptoms
31
What is the class for Thiothixene (Navane)
First-generation antipsychotics (thioxanthine)
32
What is the mechanism for Thiothixene (Navane)
ANtagonize D2 receptors
33
What are the therapeutics for Thiothixene (Navane)
Schizophrenia (hallucinations, delusions)
34
What are the important side effects for Thiothixene (Navane)
NMS
35
What are the other side effects for Thiothixene (Navane)
Extrapyramidal, tardive dyskinesia; sexual dysfunction, hyperprolactinemia
36
What are the miscellaneous for Thiothixene (Navane)
Little effect on negative symptoms
37
What is the class for Loxapine (Loxitane)
First-generation antipsychotics (dibenzoxazepine)
38
What is the mechanism for Loxapine (Loxitane)
ANtagonize D2 receptors
39
What are the therapeutics for Loxapine (Loxitane)
Schizophrenia (hallucinations, delusions)
40
What are the important side effects for Loxapine (Loxitane)
NMS
41
What are the other side effects for Loxapine (Loxitane)
Extrapyramidal (less than chlorpromazine), tardive dyskinesia; sedation (less than chlorpromazine); sexual dysfunction, hyperprolactinemia
42
What are the miscellaneous for Loxapine (Loxitane)
Little effect on negative symptoms
43
What is the class for Haloperidol (Haldol)
First-generation antipsychotics (butyrophenone)
44
What is the mechanism for Haloperidol (Haldol)
ANtagonize D2 receptors
45
What are the therapeutics for Haloperidol (Haldol)
Schizophrenia (hallucinations, delusions); severe Huntington's movement disorders (low dose)
46
What are the important side effects for Haloperidol (Haldol)
NMS
47
What are the other side effects for Haloperidol (Haldol)
Extrapyramidal (more than chlorpromazine), tardive dyskinesia; sedation (less than chlorpromazine), hypotension, anticholinergic effects; sexual dysfunction, hyperprolactinemia
48
What are the miscellaneous for Haloperidol (Haldol)
Little effect on negative symptoms
49
What is the class for Tetrabenazine (Xenazine)
Synapse depleter
50
What is the mechanism for Tetrabenazine (Xenazine)
Dopamine-depleting, VMAT2 inhibitor
51
What are the therapeutics for Tetrabenazine (Xenazine)
Improves movement disorder in Huntingtons; tardive dyskinesia
52
What are the important side effects for Tetrabenazine (Xenazine)
NMS
53
What are the miscellaneous for Tetrabenazine (Xenazine)
Occasionally used for schizophrenia
54
What is the class for Dantrolene (Dantrium)
Direct muscle relaxant
55
What is the mechanism for Dantrolene (Dantrium)
Muscle relaxant
56
What are the therapeutics for Dantrolene (Dantrium)
Malignant hyperthermia (associated with NMS); used to reverse NMS
57
What is the class for Clozapine (Clozaril)
Second-Generation Antipsychotics
58
What is the mechanism for Clozapine (Clozaril)
D2 (& D1, D4) receptor antagonist, 5HT2a receptor antagonist; NMDA antagonism
59
What are the therapeutics for Clozapine (Clozaril)
Treatment-resistant psychoses (including schizophrenia); decreases risk of suicide; can be used in pregnancy
60
What are the important side effects for Clozapine (Clozaril)
Agranulocytosis; weight gain, type II DM, seizure risk, hyperlipidemia
61
What are the other side effects for Clozapine (Clozaril)
Akathesia (rare, at high doses); GI hypomotility; myocarditis
62
What are the miscellaneous for Clozapine (Clozaril)
No catalepsy, no EPS, no TD; must monitor WBC
63
What is the class for Olanzapine (Zyprexa)
Second-Generation Antipsychotics
64
What is the mechanism for Olanzapine (Zyprexa)
D2 receptor antagonist, 5HT2a receptor antagonist
65
What are the therapeutics for Olanzapine (Zyprexa)
Schizophrenia (effective against positive symptoms, minimal effect on negative);halts mania, treats depression
66
What are the important side effects for Olanzapine (Zyprexa)
Metabolic complications (weight gain, hyperglycemia, type 2 DM, hyperlipidemia)
67
What are the other side effects for Olanzapine (Zyprexa)
Somnolence, dizziness, increased serum hepatic transaminases, postural hypotension, constipation; EPS, hyperprolactinemia, akathesia may occur
68
What are the miscellaneous for Olanzapine (Zyprexa)
More sedation and weight gain (metabolic syndrome) than "DONES"
69
What is the class for Quetiapine (Seroquel)
Second-Generation Antipsychotics
70
What is the mechanism for Quetiapine (Seroquel)
D2 receptor antagonist, 5HT2a receptor antagonist
71
What are the therapeutics for Quetiapine (Seroquel)
Schizophrenia (effective against positive symptoms, modest effect on negative)
72
What are the important side effects for Quetiapine (Seroquel)
Weight gain, hyperglycemia, postural hypotension, constipation, somnolence, dizziness
73
What are the miscellaneous for Quetiapine (Seroquel)
More sedation and weight gain (metabolic syndrome) than "DONES"
74
What is the class for Asenapine (Saphris)
Second-Generation Antipsychotic
75
What is the mechanism for Asenapine (Saphris)
D2 & 5HT2a receptor antagonist
76
What are the therapeutics for Asenapine (Saphris)
Schizophrenia; (effective against positive symptoms, not negative); stops mania
77
What are the important side effects for Asenapine (Saphris)
Weight gain, hyperglycemia, postural hypotension, constipation, insomnia, dizziness
78
What are the miscellaneous for Asenapine (Saphris)
Least problemmatic "PINE"
79
What is the class for Risperidone (Risperdal)
Second-Generation Antipsychotics
80
What is the mechanism for Risperidone (Risperdal)
D2 receptor antagonist, 5HT2a receptor antagonist
81
What are the therapeutics for Risperidone (Risperdal)
Schizophrenia (effective against positive symptoms, modest effect on negative); severe bilpolar
82
What are the important side effects for Risperidone (Risperdal)
Weight gain, hyperglycemia, postural hypotension, constipation, insomnia, dizziness, hyperprolactinemia; EPS at greater doses
83
What are the miscellaneous for Risperidone (Risperdal)
Fewer metabolic complications than "PINES"
84
What is the class for Ziprazidone (Geodon)
Second-Generation Antipsychotics
85
What is the mechanism for Ziprazidone (Geodon)
D2 receptor antagonist, 5HT2a receptor antagonist
86
What are the therapeutics for Ziprazidone (Geodon)
Schizophrenia (effective against positive symptoms, modest effect on negative)
87
What are the important side effects for Ziprazidone (Geodon)
Somnolence, cardiac arrhythmias (QTc prolongation); EPS in 5%
88
What are the miscellaneous for Ziprazidone (Geodon)
Fewer metabolic complications than "PINES"
89
What is the class for Paliperidone (Invega)
Second-Generation Antipsychotics
90
What is the mechanism for Paliperidone (Invega)
D2 receptor antagonist, 5HT2a receptor antagonist; active metabolite of risperidone after P450 metabolism
91
What are the therapeutics for Paliperidone (Invega)
Schizophrenia (effective against positive symptoms, modest effect on negative)
92
What are the important side effects for Paliperidone (Invega)
Weight gain, hyperglycemia, postural hypotension, constipation, insomnia, dizziness, hyperprolactinemia; EPS at greater doses; possible QTc prolongation
93
What are the miscellaneous for Paliperidone (Invega)
Fewer metabolic complications compared to parent drug (risperidone) and less than "PINES"
94
What is the class for Iloperidone (Eanapt)
Second-Generation Antipsychotic
95
What is the mechanism for Iloperidone (Eanapt)
D2 receptor antagonist, 5HT2a receptor antagonist
96
What are the therapeutics for Iloperidone (Eanapt)
Schizophrenia (effective against positive symptoms, modest effect on negative)
97
What are the important side effects for Iloperidone (Eanapt)
Marked alpha1 antagonism; most hypotension in class; prolongs QTC
98
What is the class for Lurasidone (Latuda)
Second-Generation Antipsychotic
99
What is the mechanism for Lurasidone (Latuda)
D2 receptor antagonist, 5HT2a receptor antagonist
100
What are the therapeutics for Lurasidone (Latuda)
Schizophrenia (effective against positive symptoms, modest effect on negative); bipolar depression
101
What are the miscellaneous for Lurasidone (Latuda)
Least weight gain of all SGAs
102
What is the class for Aripiprazole (Abilify)
Second-Generation Antipsychotics
103
What is the mechanism for Aripiprazole (Abilify)
Partial D2 and D3 receptor agonist, partial 5HT1a agonist, 5HT2a antagonist
104
What are the therapeutics for Aripiprazole (Abilify)
Schizophrenia; (effective against positive symptoms, not negative); stops mania, treats depression
105
What are the important side effects for Aripiprazole (Abilify)
Less weight side effects than the "PINES" and many of the "DRONES"; akathisia

Pharm U3 (13 decks)

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