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Pharm U3 > 2) Neuroleptics > Flashcards

2) Neuroleptics Flashcards

1
Q

What is the class for Chlorpromazine (Thorazine)

A

First-generation antipsychotics (phenothiazine); Low Potency

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2
Q

What is the mechanism for Chlorpromazine (Thorazine)

A

Antagonize D2 receptors

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3
Q

What are the therapeutics for Chlorpromazine (Thorazine)

A

Schizophrenia (hallucinations, delusions)

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4
Q

What are the important side effects for Chlorpromazine (Thorazine)

A

NMS

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5
Q

What are the other side effects for Chlorpromazine (Thorazine)

A

Extrapyramidal, tardive dyskinesia; sedation, postural hypotension (alpha1 antag); weight gain and sedation (H1 antag); anticholinergic effects

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6
Q

What are the miscellaneous for Chlorpromazine (Thorazine)

A

Little effect on negative symptoms

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7
Q

What is the class for Fluphenazine (Prolixin)

A

First-generation antipsychotics (phenothiazine); High Potency

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8
Q

What is the mechanism for Fluphenazine (Prolixin)

A

Antagonize D2 receptors

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9
Q

What are the therapeutics for Fluphenazine (Prolixin)

A

Schizophrenia (hallucinations, delusions); movement disorder in Huntingtons

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10
Q

What are the important side effects for Fluphenazine (Prolixin)

A

NMS

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11
Q

What are the other side effects for Fluphenazine (Prolixin)

A

Extrapyramidal (more than chlorpromazine), tardive dyskinesia; sedation (less than chlorpromazine), hypotension; anticholinergic effects; sexual dysfunction

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12
Q

What are the miscellaneous for Fluphenazine (Prolixin)

A

Little effect on negative symptoms

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13
Q

What is the class for Trifluoperazine (Stelazine)

A

First-generation antipsychotics (phenothiazine)

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14
Q

What is the mechanism for Trifluoperazine (Stelazine)

A

ANtagonize D2 receptors

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15
Q

What are the therapeutics for Trifluoperazine (Stelazine)

A

Schizophrenia (hallucinations, delusions)

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16
Q

What are the important side effects for Trifluoperazine (Stelazine)

A

NMS

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17
Q

What are the other side effects for Trifluoperazine (Stelazine)

A

Extrapyramidal, tardive dyskinesia; sexual dysfunction, hyperprolactinemia

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18
Q

What are the miscellaneous for Trifluoperazine (Stelazine)

A

Little effect on negative symptoms

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19
Q

What is the class for Perphenazine (Trilafon)

A

First-generation antipsychotics (phenothiazine)

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20
Q

What is the mechanism for Perphenazine (Trilafon)

A

ANtagonize D2 receptors

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21
Q

What are the therapeutics for Perphenazine (Trilafon)

A

Schizophrenia (hallucinations, delusions)

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22
Q

What are the important side effects for Perphenazine (Trilafon)

A

NMS

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23
Q

What are the other side effects for Perphenazine (Trilafon)

A

Extrapyramidal (less than chlorpromazine), tardive dyskinesia; sedation (less than chlorpromazine); sexual dysfunction, hyperprolactinemia

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24
Q

What are the miscellaneous for Perphenazine (Trilafon)

A

Little effect on negative symptoms

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25
Q

What is the class for Thioridazine (Mellaril)

A

First-generation antipsychotics (phenothiazine)

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26
Q

What is the mechanism for Thioridazine (Mellaril)

A

ANtagonize D2 receptors

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27
Q

What are the therapeutics for Thioridazine (Mellaril)

A

Schizophrenia (hallucinations, delusions)

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28
Q

What are the important side effects for Thioridazine (Mellaril)

A

NMS

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29
Q

What are the other side effects for Thioridazine (Mellaril)

A

Extrapyramidal, tardive dyskinesia; sexual dysfunction, hyperprolactinemia

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30
Q

What are the miscellaneous for Thioridazine (Mellaril)

A

Little effect on negative symptoms

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31
Q

What is the class for Thiothixene (Navane)

A

First-generation antipsychotics (thioxanthine)

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32
Q

What is the mechanism for Thiothixene (Navane)

A

ANtagonize D2 receptors

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33
Q

What are the therapeutics for Thiothixene (Navane)

A

Schizophrenia (hallucinations, delusions)

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34
Q

What are the important side effects for Thiothixene (Navane)

A

NMS

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35
Q

What are the other side effects for Thiothixene (Navane)

A

Extrapyramidal, tardive dyskinesia; sexual dysfunction, hyperprolactinemia

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36
Q

What are the miscellaneous for Thiothixene (Navane)

A

Little effect on negative symptoms

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37
Q

What is the class for Loxapine (Loxitane)

A

First-generation antipsychotics (dibenzoxazepine)

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38
Q

What is the mechanism for Loxapine (Loxitane)

A

ANtagonize D2 receptors

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39
Q

What are the therapeutics for Loxapine (Loxitane)

A

Schizophrenia (hallucinations, delusions)

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40
Q

What are the important side effects for Loxapine (Loxitane)

A

NMS

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41
Q

What are the other side effects for Loxapine (Loxitane)

A

Extrapyramidal (less than chlorpromazine), tardive dyskinesia; sedation (less than chlorpromazine); sexual dysfunction, hyperprolactinemia

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42
Q

What are the miscellaneous for Loxapine (Loxitane)

A

Little effect on negative symptoms

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43
Q

What is the class for Haloperidol (Haldol)

A

First-generation antipsychotics (butyrophenone)

44
Q

What is the mechanism for Haloperidol (Haldol)

A

ANtagonize D2 receptors

45
Q

What are the therapeutics for Haloperidol (Haldol)

A

Schizophrenia (hallucinations, delusions); severe Huntington’s movement disorders (low dose)

46
Q

What are the important side effects for Haloperidol (Haldol)

47
Q

What are the other side effects for Haloperidol (Haldol)

A

Extrapyramidal (more than chlorpromazine), tardive dyskinesia; sedation (less than chlorpromazine), hypotension, anticholinergic effects; sexual dysfunction, hyperprolactinemia

48
Q

What are the miscellaneous for Haloperidol (Haldol)

A

Little effect on negative symptoms

49
Q

What is the class for Tetrabenazine (Xenazine)

A

Synapse depleter

50
Q

What is the mechanism for Tetrabenazine (Xenazine)

A

Dopamine-depleting, VMAT2 inhibitor

51
Q

What are the therapeutics for Tetrabenazine (Xenazine)

A

Improves movement disorder in Huntingtons; tardive dyskinesia

52
Q

What are the important side effects for Tetrabenazine (Xenazine)

53
Q

What are the miscellaneous for Tetrabenazine (Xenazine)

A

Occasionally used for schizophrenia

54
Q

What is the class for Dantrolene (Dantrium)

A

Direct muscle relaxant

55
Q

What is the mechanism for Dantrolene (Dantrium)

A

Muscle relaxant

56
Q

What are the therapeutics for Dantrolene (Dantrium)

A

Malignant hyperthermia (associated with NMS); used to reverse NMS

57
Q

What is the class for Clozapine (Clozaril)

A

Second-Generation Antipsychotics

58
Q

What is the mechanism for Clozapine (Clozaril)

A

D2 (& D1, D4) receptor antagonist, 5HT2a receptor antagonist; NMDA antagonism

59
Q

What are the therapeutics for Clozapine (Clozaril)

A

Treatment-resistant psychoses (including schizophrenia); decreases risk of suicide; can be used in pregnancy

60
Q

What are the important side effects for Clozapine (Clozaril)

A

Agranulocytosis; weight gain, type II DM, seizure risk, hyperlipidemia

61
Q

What are the other side effects for Clozapine (Clozaril)

A

Akathesia (rare, at high doses); GI hypomotility; myocarditis

62
Q

What are the miscellaneous for Clozapine (Clozaril)

A

No catalepsy, no EPS, no TD; must monitor WBC

63
Q

What is the class for Olanzapine (Zyprexa)

A

Second-Generation Antipsychotics

64
Q

What is the mechanism for Olanzapine (Zyprexa)

A

D2 receptor antagonist, 5HT2a receptor antagonist

65
Q

What are the therapeutics for Olanzapine (Zyprexa)

A

Schizophrenia (effective against positive symptoms, minimal effect on negative);halts mania, treats depression

66
Q

What are the important side effects for Olanzapine (Zyprexa)

A

Metabolic complications (weight gain, hyperglycemia, type 2 DM, hyperlipidemia)

67
Q

What are the other side effects for Olanzapine (Zyprexa)

A

Somnolence, dizziness, increased serum hepatic transaminases, postural hypotension, constipation; EPS, hyperprolactinemia, akathesia may occur

68
Q

What are the miscellaneous for Olanzapine (Zyprexa)

A

More sedation and weight gain (metabolic syndrome) than “DONES”

69
Q

What is the class for Quetiapine (Seroquel)

A

Second-Generation Antipsychotics

70
Q

What is the mechanism for Quetiapine (Seroquel)

A

D2 receptor antagonist, 5HT2a receptor antagonist

71
Q

What are the therapeutics for Quetiapine (Seroquel)

A

Schizophrenia (effective against positive symptoms, modest effect on negative)

72
Q

What are the important side effects for Quetiapine (Seroquel)

A

Weight gain, hyperglycemia, postural hypotension, constipation, somnolence, dizziness

73
Q

What are the miscellaneous for Quetiapine (Seroquel)

A

More sedation and weight gain (metabolic syndrome) than “DONES”

74
Q

What is the class for Asenapine (Saphris)

A

Second-Generation Antipsychotic

75
Q

What is the mechanism for Asenapine (Saphris)

A

D2 & 5HT2a receptor antagonist

76
Q

What are the therapeutics for Asenapine (Saphris)

A

Schizophrenia; (effective against positive symptoms, not negative); stops mania

77
Q

What are the important side effects for Asenapine (Saphris)

A

Weight gain, hyperglycemia, postural hypotension, constipation, insomnia, dizziness

78
Q

What are the miscellaneous for Asenapine (Saphris)

A

Least problemmatic “PINE”

79
Q

What is the class for Risperidone (Risperdal)

A

Second-Generation Antipsychotics

80
Q

What is the mechanism for Risperidone (Risperdal)

A

D2 receptor antagonist, 5HT2a receptor antagonist

81
Q

What are the therapeutics for Risperidone (Risperdal)

A

Schizophrenia (effective against positive symptoms, modest effect on negative); severe bilpolar

82
Q

What are the important side effects for Risperidone (Risperdal)

A

Weight gain, hyperglycemia, postural hypotension, constipation, insomnia, dizziness, hyperprolactinemia; EPS at greater doses

83
Q

What are the miscellaneous for Risperidone (Risperdal)

A

Fewer metabolic complications than “PINES”

84
Q

What is the class for Ziprazidone (Geodon)

A

Second-Generation Antipsychotics

85
Q

What is the mechanism for Ziprazidone (Geodon)

A

D2 receptor antagonist, 5HT2a receptor antagonist

86
Q

What are the therapeutics for Ziprazidone (Geodon)

A

Schizophrenia (effective against positive symptoms, modest effect on negative)

87
Q

What are the important side effects for Ziprazidone (Geodon)

A

Somnolence, cardiac arrhythmias (QTc prolongation); EPS in 5%

88
Q

What are the miscellaneous for Ziprazidone (Geodon)

A

Fewer metabolic complications than “PINES”

89
Q

What is the class for Paliperidone (Invega)

A

Second-Generation Antipsychotics

90
Q

What is the mechanism for Paliperidone (Invega)

A

D2 receptor antagonist, 5HT2a receptor antagonist; active metabolite of risperidone after P450 metabolism

91
Q

What are the therapeutics for Paliperidone (Invega)

A

Schizophrenia (effective against positive symptoms, modest effect on negative)

92
Q

What are the important side effects for Paliperidone (Invega)

A

Weight gain, hyperglycemia, postural hypotension, constipation, insomnia, dizziness, hyperprolactinemia; EPS at greater doses; possible QTc prolongation

93
Q

What are the miscellaneous for Paliperidone (Invega)

A

Fewer metabolic complications compared to parent drug (risperidone) and less than “PINES”

94
Q

What is the class for Iloperidone (Eanapt)

A

Second-Generation Antipsychotic

95
Q

What is the mechanism for Iloperidone (Eanapt)

A

D2 receptor antagonist, 5HT2a receptor antagonist

96
Q

What are the therapeutics for Iloperidone (Eanapt)

A

Schizophrenia (effective against positive symptoms, modest effect on negative)

97
Q

What are the important side effects for Iloperidone (Eanapt)

A

Marked alpha1 antagonism; most hypotension in class; prolongs QTC

98
Q

What is the class for Lurasidone (Latuda)

A

Second-Generation Antipsychotic

99
Q

What is the mechanism for Lurasidone (Latuda)

A

D2 receptor antagonist, 5HT2a receptor antagonist

100
Q

What are the therapeutics for Lurasidone (Latuda)

A

Schizophrenia (effective against positive symptoms, modest effect on negative); bipolar depression

101
Q

What are the miscellaneous for Lurasidone (Latuda)

A

Least weight gain of all SGAs

102
Q

What is the class for Aripiprazole (Abilify)

A

Second-Generation Antipsychotics

103
Q

What is the mechanism for Aripiprazole (Abilify)

A

Partial D2 and D3 receptor agonist, partial 5HT1a agonist, 5HT2a antagonist

104
Q

What are the therapeutics for Aripiprazole (Abilify)

A

Schizophrenia; (effective against positive symptoms, not negative); stops mania, treats depression

105
Q

What are the important side effects for Aripiprazole (Abilify)

A

Less weight side effects than the “PINES” and many of the “DRONES”; akathisia

Pharm U3 (13 decks)

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