2) Neuroleptics Flashcards
What is the class for Chlorpromazine (Thorazine)
First-generation antipsychotics (phenothiazine); Low Potency
What is the mechanism for Chlorpromazine (Thorazine)
Antagonize D2 receptors
What are the therapeutics for Chlorpromazine (Thorazine)
Schizophrenia (hallucinations, delusions)
What are the important side effects for Chlorpromazine (Thorazine)
NMS
What are the other side effects for Chlorpromazine (Thorazine)
Extrapyramidal, tardive dyskinesia; sedation, postural hypotension (alpha1 antag); weight gain and sedation (H1 antag); anticholinergic effects
What are the miscellaneous for Chlorpromazine (Thorazine)
Little effect on negative symptoms
What is the class for Fluphenazine (Prolixin)
First-generation antipsychotics (phenothiazine); High Potency
What is the mechanism for Fluphenazine (Prolixin)
Antagonize D2 receptors
What are the therapeutics for Fluphenazine (Prolixin)
Schizophrenia (hallucinations, delusions); movement disorder in Huntingtons
What are the important side effects for Fluphenazine (Prolixin)
NMS
What are the other side effects for Fluphenazine (Prolixin)
Extrapyramidal (more than chlorpromazine), tardive dyskinesia; sedation (less than chlorpromazine), hypotension; anticholinergic effects; sexual dysfunction
What are the miscellaneous for Fluphenazine (Prolixin)
Little effect on negative symptoms
What is the class for Trifluoperazine (Stelazine)
First-generation antipsychotics (phenothiazine)
What is the mechanism for Trifluoperazine (Stelazine)
ANtagonize D2 receptors
What are the therapeutics for Trifluoperazine (Stelazine)
Schizophrenia (hallucinations, delusions)
What are the important side effects for Trifluoperazine (Stelazine)
NMS
What are the other side effects for Trifluoperazine (Stelazine)
Extrapyramidal, tardive dyskinesia; sexual dysfunction, hyperprolactinemia
What are the miscellaneous for Trifluoperazine (Stelazine)
Little effect on negative symptoms
What is the class for Perphenazine (Trilafon)
First-generation antipsychotics (phenothiazine)
What is the mechanism for Perphenazine (Trilafon)
ANtagonize D2 receptors
What are the therapeutics for Perphenazine (Trilafon)
Schizophrenia (hallucinations, delusions)
What are the important side effects for Perphenazine (Trilafon)
NMS
What are the other side effects for Perphenazine (Trilafon)
Extrapyramidal (less than chlorpromazine), tardive dyskinesia; sedation (less than chlorpromazine); sexual dysfunction, hyperprolactinemia
What are the miscellaneous for Perphenazine (Trilafon)
Little effect on negative symptoms
What is the class for Thioridazine (Mellaril)
First-generation antipsychotics (phenothiazine)
What is the mechanism for Thioridazine (Mellaril)
ANtagonize D2 receptors
What are the therapeutics for Thioridazine (Mellaril)
Schizophrenia (hallucinations, delusions)
What are the important side effects for Thioridazine (Mellaril)
NMS
What are the other side effects for Thioridazine (Mellaril)
Extrapyramidal, tardive dyskinesia; sexual dysfunction, hyperprolactinemia
What are the miscellaneous for Thioridazine (Mellaril)
Little effect on negative symptoms
What is the class for Thiothixene (Navane)
First-generation antipsychotics (thioxanthine)
What is the mechanism for Thiothixene (Navane)
ANtagonize D2 receptors
What are the therapeutics for Thiothixene (Navane)
Schizophrenia (hallucinations, delusions)
What are the important side effects for Thiothixene (Navane)
NMS
What are the other side effects for Thiothixene (Navane)
Extrapyramidal, tardive dyskinesia; sexual dysfunction, hyperprolactinemia
What are the miscellaneous for Thiothixene (Navane)
Little effect on negative symptoms
What is the class for Loxapine (Loxitane)
First-generation antipsychotics (dibenzoxazepine)
What is the mechanism for Loxapine (Loxitane)
ANtagonize D2 receptors
What are the therapeutics for Loxapine (Loxitane)
Schizophrenia (hallucinations, delusions)
What are the important side effects for Loxapine (Loxitane)
NMS
What are the other side effects for Loxapine (Loxitane)
Extrapyramidal (less than chlorpromazine), tardive dyskinesia; sedation (less than chlorpromazine); sexual dysfunction, hyperprolactinemia
What are the miscellaneous for Loxapine (Loxitane)
Little effect on negative symptoms