3B physiology of the liver P3 Flashcards
what is the most common phospholipid found in bile
Lecithin
recall the phopholipids are also ________
amphipathic
what amount of cholesterol are converted to bile acids and eliminated in bile every day
500mg
some cholesterol is also eliminated in the bile as ____ ____-
waste products
what is bilirubin
waste product of hemoglobin degradation
what are the two types of bilirubin
free bilirubin or unconjugated bilirubin or indirect bilirubin
and
conjugated bilirubin or direct bilirubin
how is free bilirubin transported in the blood
attached to albumin, conjugated bilirubin or direct bilirubin
as free bilirubin passes through the liver, it is released from albumin and moved into hepatocytes which perform the following functions
1) uptake of bilirubin from the circulation
2) conjugatioin of bilirubin
3) excretion of bilirubin into the bile
conjugation involved attaching _____ _____ to bilirubin in a reaction catalyzed by the enzyme _____ ______
glucoronic acid, glucoronyl transferase
______ bilirubin is much more water soluble then free or _____ bilirubin
conjugated, unconjugated
how are Ions and water secreted
by epithelial cells lining the bile ducts
list misc. bile constituants
lipothilic drugs
metabolites
antigen-antibody complexes
review bile synthesis on slides 37-39
do it now
the first two steps of bile synthesis produces how much hepatic bile per day
900ml
during meals, the bile that reaches the duodenum is a mixture of relatively ________ hepatic bile and ________ gall bladder bile
dilute, concentreted
