3B physiology of the liver Flashcards
what percentage of weight can the liver store as glycogen
8% (100-120 g in an adult)
where is the bulk of glycogen stored in the body
in the muscle
where does the mass majority of amono acid degredation occur
In the liver (with Deamination)
what two SET of enzymes are required for Deamination
aminotransferases and transaminases
what is SGOT (serum glutamate oxaloacetete thansaminase) also known as
aspartate transaminase (AST)
what is another name for SGBT (serum glutamate-pyruvate transaminase)
alanine transamanase (ALT)
AST and ALT have _______ purpose, they are also used to synthesize ___________ amino acids within liver hepatocytes
Duel, non-essential
what are high blood levels of ALT and AST indicitive of
Liver disease
in serious liver disease, ammonia can often accumulate in the blood and lead to a state called _______ ______ or ______ ______
hepatic coma, hepatic encepholopathy
what are amine groups ultimately converted to
Urea
a build up of urea in the blood can lead to a state of _______ or ______
azotemia or uremia
elevated BUN (blood urea nitrogen) can occur with
- impaired renal function
- increased protein intake of catabolism
- GI bleeding (due to intestinal flora creating nitrogenous wast)
- dehydration
what is the normal Level for BUN in the adult
5-26mg/dL
what enzyme in needed for cholesterol synthesis
HMG-CoA reductase
what is the only way to get rid of excess cholesterol
Via Bile
