3B more exchange Flashcards
why is food broken down into smaller molecules during digestion
as the large biological molecules are to big to cross cell membranes and be absorbed from the gut into the blood
what are digestive enzymes produced by
specialised cells in the digestive system
why do different enzymes needed to catalyse the breakdown of different food molecules
as enzymes only work with specific substrate
what are carbohydrates broken down by
amylase and membrane bound disaccharide
what does amylase catalyse starch conversion into
maltose
where is amylase produced
salivary glands- into mouth
pancreas- into small intestine
what are membrane bound disaccharide
enzymes which are attached to the cell membranes of epithelial cells lining the ileum
what do membrane bound disaccharide do
help break down disaccharide into monosaccharides
involves hydrolysis
what is the ileum
final part of small intestine
how can monosaccharides be transported across cell membrane of the ileum epithelium cells
via transporter proteins
what are lipids broken down by
lipase with the help of bile salts
what does lipase catalyse the breakdown of lipids into
monoglycerides and fatty acids
where is lipase made
made in pancreas
works in small intestine
where are bile salts produced
liver
what does bile slats do
emulsifies lipids into small droplets
why are bile salts so important
as they emulsify lipid into small droplets which largely increases the surface area and therefore increases the rate of diffusion as there is more area for lipase to work on
once lipids are broken down what do monoglycerides and fatty acids stick to bile salts to form
micelles
what are proteins broken down by
endopeptidases and exopeptidase
what are endopeptidases
they act to hydrolyse peptide bonds within a protein
what are two examples of endopeptidases
and where are they found
chymotrypsin and trypsin
both synthesised in pancreases and secreted in small intestine
details on pepsin (another endopeptidase)
released into stomach by cells in the stomach lining
only works in acidic conditions- what hydrochloric acid is for in the stomach
what is exopeptidase
acts to hydrolyse peptide bonds at the end of protein molecules
removes single amino acid from proteins
what are dipeptidases
exopeptidase that only work on dipeptides
how do dipeptidases work
they separate the two amino acids which make up the dipeptide by hydrolysing the peptide bond between
where are dipeptidases located
found on cell surface membrane of epithelial cells in small intestine
what are the products of digestion absorbed across
the ileum epithelium into the blood stream
how is glucose and galactose absorbed
by active transport with sodium ions via co transporter proteins
how are monoglycerides and fatty acids absorbed
micelles help move them towards epithelium
micelles release them allowing them to be absorbed
why can monoglycerides and fatty acids be absorbed across the epithelial cell membrane
as they are lipid soluble
how are amino acids absorbed
absorbed via co transport
sodium ions actively transported out of the ileum epithelial cells into the blood
creates sodium conc grad
Sodium ions diffused from lumen of ileum into epithelial cells through sodium dependent transporter proteins carrying amino acids with
How are proteins digested
Hydrolysis of peptide bonds
Endopeptidases breaks down polypeptides into smaller peptides
exopeptidases removes terminal Amino acid
Dipeptidase breaks down dipeptides into amino acids
Why is maltose only digested by Maltese
Maltase has specific active site shape
Only binds to maltose
To form an enzyme substrate complex
describe haemoglobin
large protein with quaternary structure
what does quaternary structure mean
made up of more than one polypeptide chain
in haemoglobin what is a haem group and what does it contain
each chain has haem group
contains an iron ion giving the red colour
why is haemoglobin described as having a high affinity for oxygen
each molecule can carry four oxygen molecules
how and where is oxyhemoglobin formed
oxygen joins to haemoglobin in red blood cells forming oxyhemoglobin
this takes place in the lungs
what is the equation of the reversible reaction oxyhaemaglobin to haemoglobin
Hb + 4O2 Hb08
what is the partial pressure of oxygen
pO2
measure of oxygen concentration
higher conc of dissolved o2 in cells= higher partial pressure
what is the partial pressure of c02
pCO2 measure of concentration of carbon dioxide in cell
how does haemoglobin affinity for oxygen depend on the partial pressure of oxygen
oxygen loads onto haemoglobin to form oxyhemoglobin where there’s a high po2
oxyhemoglobin unloads its oxygen when there is a low pO2
why does oxygen load onto haemoglobin in the alveoli
as The alveoli have a high p02
where does oxyhemoglobin unload its oxygen
in respiring cells as they have low pO2
how does pCO2 effect oxygen unloading
haemoglobin gives up its oxygen more readily at higher partial pressures of carbon dioxide