3.2.3 Surfactant Structure - Function Flashcards
How can a defect in SP-B lead to RDS?
Phosphatidyl ethanolamine and serine combine to for what?
Surfactant is secreted from the T2 pneumocyte in a?
Lamellar body
What is important about the L/S ratio an lung maturation?
The critical value of L/S ratio is 2.
After a series of reaction Serine yields CDP-ethanolamine. This combines with what to yield what?
Diacylglycerol to yield PE
What are the steps of sphingomyeline synthesis?
What are the two most important lipids in generating surfactant?
Lecithen and sphingomyelin
How is surfactant sent to the surface?
What are some of the roles of SP-A and SP-D?
What occurs in fetal development between the 32nd and 36th week?
This allows for an increase in the L/S levels
When looking at these TLC results of L/S ratios which would be worrysome?
A - Normal ratio
B - 1.6 - should mature more
C - 0.8 Worrysome
What is some post-natal treatment of RDS?
What is this?
Phosphatidyl Glycerol (PG)
What is this?
What is this an image of?
What are some methods to aid in RDS?
CDP - diacylglycerol and Inositol combine to form what?
What are some other causes of RDS?
Also protease excess caused by smoking.
What is the basic process for the synthesis of dipalmitoylphosphatidylcholine (lecithin)?
What are the important proteins in SURFactant?
SP - A, B, C, D
What is the best test that can be done to measure the L/S ratio?
TLC
What is this an image of?
What is the precursor to both phospholipids and triacylglycerides?
Phosphatidic acid
What is the role of surfactant in preventing atelectasis?
How can a mutation in ABCA3 lead to RDS?
What week of gestation does Lecithen begin to increase markedly?
Wk 32ish
What happens to the levels of phosphatidylcholine, phosphatidylglycerol, phosphatidylinotisol and sphingomyelin synthesis during the 32nd to 36th week?
How can defects in SP-C lead to RDS?
Diacylglycerol combines with CDP-choline to yield?
