317 Midterm Flashcards
Name the three perspectives of aging
Biological age
Sociological age
Psychological age
Biological age
Measures of anatomical and physiological changes that reduce functional capacities and physiological reserves
Sociological age
Focuses on the roles and behaviors of people in response to the society of which they are part
Psychological age
Refers to the behavior of people as they adapt to changing environmental demands
Gene regulation theory
Aging is caused by changes in the expression of genes
Emphasis upon role of genetics in longevity
Often applied to centenarians
Cross-linkage theory
With age chemical reactions bind together molecules that should be separated, increasing rigidity and instability of cells
Explanation for aging of connective tissue and collagen
Decreased elasticity and cataracts via protein linkage in lens
Senescence
Progressive deterioration that causes an increase in vulnerability to challenges and decreasing ability to survive.
Free radical theory
Free radicals interfere with cell function
Contributed via smoking and obesity
What provides defense against free radicals?
Antioxidants like vitamin C and vitamin E
Apoptosis theory
Regulated cell death
Triggered by DNA damage, oxidative stress, and anoxia, and ultraviolet radiation
Possible explanation for loss of lymphocytes/neurodegenerative diseases
Inhibited apoptosis may…
Explain increased malignancies
Wear and Tear theory
Obsolete with the exception of osteoarthritis
System-based theories claim that
The aging process is due to the decline of organ systems involved in regulation and adaptability.
Name the 2 system-based theories
Neuroendocrine Theory
Immune Theory
Neuroendocrine theory
With aging, endocrine system fails to regulate organs
Immunity Theory
Decreased immunity results in aging
Immunosenescense, the aging immune system, is characterized by decreased resistance to infection and…
Failure to recognize self (autoimmune disorders)
What age related diseases would immunity research focus on…
Alzheimer’s Disease
Osteoarthritis
CV disease