3.14 Antigen Processing and Presentation

Question 1

Antigen presentation to naive/effector T cells may result to either __ or __

Answer 1

• activation of naive T cell to become effector cells

- activation of effector T cells to further cause cellular cleaving

Question 2

Protein that trims peptides to appropriate size, functional during the MHC Class I Pathway

Answer 2

ER resident aminopeptidase protein

Question 3

Facilitates entry of foreign antigens from the cytosol to the ER during MHC Class I Pathway

Answer 3

Transporter associate with antigen processing

Question 4

Facilitates the peptide exchange in MHC Class II (CLIP with processed peptides)

Answer 4

HLA-DM

Question 5

Difference between the peptides recognized by CD8 and CD4

Answer 5

CD8: recognize peptides derived from cytosol (endogenously synthesized)
CD4: recognize peptides derived from extracellular proteins

Question 6

Response to the two signal by dendritic cells

Answer 6

Signal 1 - recognition of antigen

Signal 2 - immune response by APC