3.06 Hemostasis Flashcards
Lyses or dissolves the clot
Fibrinolytic system
First cellular evidence when there is a break in the endothelium to stop the bleeding
Platelet system
It is the reactive lining of the blood vessel
Basement membrane
Helps with platelet adhesion and aggregation and it releases tissue factor which plays a significant part in the clotting cascade
vWF
Down regulates thrombin formation and prostacyclin
Protein C
A potent vasodilator that resumes original blood flow; inhibits platelet aggregation in healthy vessels
Prostacyclin
The first response to an injury
Blood vessel contraction
For platelet adhesion, platelet should bind to the vWF through the ______ and to collagen through the _______
Gp1b receptor. Gp1a receptor.
Stimulates platelet aggregation. (2 factors)
ADP and Ca2+
Stimulates vascular spasms
Thromboxane A2
Clotting factor that do not usually participate in clotting in vivo
XII
At each stage, a precursor is converted to an activated protease in the presence of these two factors
Calcium and phospholipid factors
2 factors that must be present in the liver for this cascade to proceed to completion.
Calcium ions and Vitamin K.
Converts soluble fibrinogen into soluble fibrin
Thrombin
Factor that is responsible for the mesh formation of the clot
Factor XIII
Merger of the extrinsic and intrinsic pathways.
Common pathway
Which between the intrinsic and extrinsic pathway is the feedback loop?
Intrinsic pathway
Inhibits thrombin formation and Factor Xa. Absence of this results thromboembolism or thrombotic episodes.
Antithrombin