3: Mood Disorders Flashcards
How are mood disorders classified?
depressive or maniac episodes
- each have key symptoms associated with both
What are the cirterias to be diagnosed with a mood disorder?
- depressive/ maniac episodes must be severe enough that it is causing significant impairment in their social + occupational function
- episodes should not be explained by other external factors like medication/ other disorders
- for depressive = must not be the result of bereavement
What are the subdivision within depressive disorders?
- major depressive disorder
- dsythymic disorder
- disruptive mood dsyregulation disorder
- premenstrual dysphoric disorder
Describe major depressive disroder
- single or recurrant episodes of depression
- where symptoms last for more than 2 months
Describe dsythymic disorder
- persistent depressive disorder
- similar symptoms to major depression but less severe
- but last much longer like 2 yrs
Describe disruptive mood dsyregulation disorder
- severe recurring temper tantrums
- verbal/ behavioural nature
Describe premenstrual dysphoric disorder
mood swings associated with phases of menstrual cycle
Describe bipolar disorder
- extreme fluctuation in mood
- alt between depression + mania
- og called manic depression
What are the 3 subtypes of bipolar disorder?
Bipolar I D
Bipolar II D
Cylcothymic disorder
What is hypomania?
- symptoms similar to those in mania
- but not sever enough to impair functioning
so = less severe form of mania
What is the difference between bipolar I vs II?
I = depressive/ manic/ hypomaic episodes present
- previous manic/ depressive episode may have been present
- psychosis also may be present
II = major depression/ hypomanic episodes
- history of at least one episode of major depression/ hypomania
Describe Cylcothymic disorder, one of the subtypes of bipolar diorder
- within 2 yrs = cycle of hypomanic episodes at w/ depressive symptoms
- major depression not severe enough = major depression
- no history of major depression/ mania
Who is Nathalie?
- og quiet person + periods of depression
- sudden change in energy + xp grandiose delusions
= diagnosed with bipolar I
What is…
- Rapid cycling
- Ultra-rapid cycling
- Ultradian cycling
The different cycling nature of bipolar disorder:
- 4+ episodes of manic/ hypomanic + depressive symptoms within one year
- Extreme fluctuation over a period of days
- Extreme fluctuation within the same day
What are some symptoms of someone experiencing a manic episode?
- extremely elevated mood
- grandiose ideas
- flight of ideas
- Distractibility
Some patients can have both manic + depressive episodes together. Why is this particularly dangerous?
- increased risk of suicide
- recurring thoughts of death + impulsivity (Swann et al, 2007)
What are the monoamine neurotransmitter?
Dopamine, serotonin + norepinephrine
Which genes have been suggested to have a role in the development of depression?
- Seretonin transporter gene
- stress –> depletion of neurotransmitter - DRD4 - dopamine D4 receptor
How is stress related to development of depression (Karg, Burmeister, Shedden + Sen, 2011)?
depressed patients = higher cortisol lvls than others
- increased prolonged reactivity to stressor may deplete neurotransmitter system, esp serotonin (Leonard, 2010)
What is the circadian rhythm?
describes the cyclical physiological changes than occur within an organism over a repeated time period
eg 24hr sleep-wake cycle
How has the circadian rhythm been suggested to have a role in the development of depression?
dsyfunctional central regulator which controls circadian rhythm found in depression (Germain + Kupfer, 2008)
Which neuroanatomical parts of the brain are suggested to have a role in the development of depression?
- Pre-frontal cortex
- reduced activity
(Davidson + Pizzagalli, Nitschke + Putnam, 2002) - Hippocampus
- reduced size in depressed patients
(Malhi + Lagopoulos, 2008)
What is thought to be the role of the pre-frontal cortex, related to depression?
control fear response from the limbic system esp amygdala
- no control = fear response manifests eg anxiety - symptom of depression
What is thought to be the role of the hippocampus, related to depression?
learning + memory
- memory impairment eg memory recollection mediated by hippocampus (Campbell + MacQueen, 2004)