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GIHEP > 3. Acute and Chronic Hepatitis > Flashcards

3. Acute and Chronic Hepatitis Flashcards

1
Q

What inflammatory cell is always present in hepatitis?

A

Lymphocyte

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2
Q

What viruses cause hepatitis?

A

Hep viruses
EBV
CMV
Rubella

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3
Q

What are the signs of acute hepatitis?

A 
Enlarged tender liver
Jaundice
High AST and ALT
high bilirubin but normal albumin
Lengthened prothrombin time
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4
Q

What are the causes of chronic hepatitis?

A 
Viral
Drugs
Auto-immune
Wilson's disease
A1ATD
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5
Q

What are the methods of assessing chronic hepatitis?

A

Blood tests
Viral load
Grade and stage
Fibroscan

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6
Q

What is the only DNA hepatitis virus?

A

B

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7
Q

What hep B antigen is present when the virus is replicating?

A

HBeAg

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8
Q

What causes damage to the liver in hep B?

A

Body’s immune response

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9
Q

What are the signs of active hep B infection on serology?

A

HBsAg
IgM anti-HBc
Viral DNA
High ALT

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10
Q

What are the signs of resolved hep B infection on serology?

A

Anti-HBs

Anti-HBc

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11
Q

What are the signs of hep B vaccination on serology?

A

anti-HBs

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12
Q

What are the infection phases in hep B?

A

Replicative, immune tolerance
Replicative, immune response
Non-replicative, immune control
Replicative, immune escape

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13
Q

Who is most likely to be in the replicative, immune tolerance phase of hep B?

A

Infants who were exposed perinatally

No immune response so asymptomatic

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14
Q

What happens in the replicative immune response phase?

A

Tolerance wanes, or happens if infected is an adult

Immune system begins to seroconvert HBeAg to antibody

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15
Q

What is the non-replicative immune control phase?

A

Asymptomatic carriers; virus is no longer replicating

disease progress halted

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16
Q

What happens in the replicative immune escape phase?

A

Reactivation due to mutant strain or immune suppression

17
Q

Which hepatitis antibodies are protective against getting the same virus?

A

A is protective

C is not

18
Q

How many serotypes of hep C are there?

A

6

19
Q

What is the goal of hep C treatment?

A

No RNA detected 12 weeks after treatment

GIHEP (30 decks)

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