3/31/13 Flashcards

1
Q

What is the state of the uterus in placental abruption?

A

undergoing painful contractions or w/ excess tone

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2
Q

What do you call vaginal bleeding occurring @ >20 gestation?

A

antepartum vaginal bleeding

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3
Q

What is the most common cause of painless antepartum bleeding?

A

placenta previa

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4
Q

When treating pts w/ gestational diabetes, what is the ideal range of maternal fasting glucose?

A

75-90 mg/dL

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5
Q

What is the immediate cause of the hyperviscosity of the blood that may occur in the infant of a diabetic mother?

A

polycythemia

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6
Q

What cause polycythemia in an infant of a diabetic mother?

A

fetal hypoxia d/t increased basal metabolic rate d/t hyperglycemia

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7
Q

What is the reason for hypocalcemia in infants of diabetic mothers?

A

parathyroid hormone suppression (by insulin)

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8
Q

In pts w/ androgen insensitivity syndrome, what causes breast development?

A

conversion of testosterone to estrogen

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9
Q

When should a gonadectomy be performed in pts with androgen insensitivity syndrome (AIS)?

A

after puberty

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10
Q

What therapy should be instituted in pts w/ AIS after gonadectomy?

A

estrogen replacement

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11
Q

Why doesn’t progesterone need to be given to pts w/ AIS post-gonadectomy?

A

no uterus!

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12
Q

In what condition is a person phenotypically female w/ an XY karyotype and the gonads must be removed immediately?

A

XY gonadal dysgenesis (Swyer syndrome)

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13
Q

What are the gonads like in Swyer syndrome?

A

streak gonads

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14
Q

Describe the genitalia of a person w/ XY gonadal dysgenesis?

A

completely normal female genitalia except that there are no ovaries (or testicles), only undifferentiated “streak” gonads

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15
Q

What is the basic pathogenetic cause of Swyer syndrome?

A

failure of the gonads to differentiate

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16
Q

What gene is commonly mutated in XY gonadal dysgenesis?

A

SRY

17
Q

Why do the uterus and Fallopian tubes develop in Swyer syndrome, unlike in AIS?

A

no AMH is released by gonads

18
Q

Why don’t pts w/ Swyer syndrome develop breasts?

A

no testosterone produced by gonads

19
Q

Why do pts w/ SAwyer syndrome develop pubic/axillary hair?

A

small amts of androgens produced by adrenals