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Imhotep 2 > 3/26/16 > Flashcards

3/26/16 Flashcards

1
Q

HALT (target cells)

A

Hemogloglobin C
Asplenia
Liver disease
Thalassemia

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2
Q

Categorical Test (ex: race); NOT numerical in nature

A

Chi-square test

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3
Q

Dependent T- test vs. Independent-T test

A

Dependent: Used to analyze the mean of one group at two different times
Independent: Used to analyze the mean in TWO groups at ONE time

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4
Q

In Job syndrome (HYPER-IgE) HELPER T-cells are failing to produce what?

A

IFN-gamma leading to an inability of neutrophils to respond to chemotactic stimuli (skin infections/ afebrile due to lack of inflammatory response)
“Course Facies”

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5
Q

LFA-1 integrin on phagocytes (used to bind ICAM-I)

Defective in LAD

A

CD18

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6
Q

Thayer-Martin Media contains:

A

Vancomycin, Colistin (polymixin), and nystatin

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7
Q

Yellow fever and smallpox vaccines

A

Live attenuated vaccine that induces both cell mediated and humoral
Inactivated vaccines such as Influenza only produces B-cell/Humoral immunity

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8
Q

Class III antiarrhythmic agent

Prolongs repolarization by blocking outward potassium conductance (prolongs QT interval) … No effect on QRS

A

Sotalol

LEARN ANTI-ARRYTHMICS

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9
Q

Raloxifene vs Tamoxifen

A

Raloxifene (also used in osteoporosis) is a much better option if the patient hasn’t had a hysterectomy because unlike Tamoxifen it is an ANTAGONIST in both the breast and endometrium

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10
Q

Indinavir (protease inhibit for HIV) ADR:

A

Thrombocytopenia

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11
Q

Pellagra

A 
3Ds
Dermatitis
Diarrhea
Dementia
Tx= Niacin (know side effects)
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12
Q

Angular stomatitis, cheilosis (inflammation of the lips), and corneal vascularization

A

Deficiency of Riboflavin (vitamin B2)

look up vitamin deficiencies ex. E

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13
Q

Negative symptoms of schizo

A 
Poverty of speech
Flat affect
Amotivation
Disinterest in forming relationships
(Note: meds do not really help these symptoms if even do tho it is the atypicals)
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14
Q

Phenotypical female with normal levels of testosterone, estrogen, and luteinizing hormone. However, infant has bilateral testes and a normal male internal urogenital tract

A

5-alpha reductase deficiency

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15
Q

Phenotypically female but has bilateral testes that are undescended or located in the labia majora. Levels of LH, estrogen and testosterone are HIGH

A

Complete androgen insensitivity / Testicular feminization syndrome

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16
Q

Ovaries are present and the external genitalia are virilized or ambiguous

A

Female pseudohermaphroditism usually due to exposure to androgens early in gestation
(Note: a true hermaphrodite is when a person has testicular and ovarian tissue)

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17
Q

A band = absolute length of myosin

A

Does not change in size upon contraction

H and I bands however do get smaller

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18
Q

Tx for Addison’s disease

A

Exogenous glucocorticoids (dexamethasone, hydrocortisone) and mineralocorticoids (fludrocortisone to correct electrolyte imbalance)

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19
Q

Name the drug that acts on the same transporter that the disease affects:

A

Gitelman syndrome and Bartter syndrome
Gitelman syndrome= HCTZ
Bartters= Furosemide

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20
Q

Negative or positive skew

A

Mode>median>Mean

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21
Q

Increases when left ventricle is underfilled (as in tachycardia or Valsalva maneuver)
Decreases when left ventricle filling is increased (squatting)

A

S4 murmur of hypertrophic cardiomyopathy (HCM): Increases when? Decreases when?

22
Q

HCM treatment

A

B-blockers like atenolol that reduces myocardial contractility and lower HR increasing ventricular filling and reducing outflow gradient
Or
Non-DHP Ca2+ blockers like verapamil

23
Q

Call-Exner bodies (fluid filled cavities with a “rosette” appearance

A

Granulosa cell tumors (hyperestrogenism)

24
Q

Class IA ADR

A

Prolong QT interval Torsades de pointes

25
Q

Acyclovir must be activated by what:

A

Thymidine kinase

26
Q

Split basement membrane when staining for mutated collagen

A

Alports disease IF

(mutated type IV collagen–> GBM dysfucntion, sensorineural hearing loss, ocular lesions

27
Q

BEP regimen for testicular cancer

A

bleomycin, Etoposide, cisplatin

Note: Bleomycin can cause pulmonary fibrosis and hyperpigmentation

28
Q

Cytarabine (ara-C)

A

AML Tx

29
Q

Question describes a girl (really a boy) whose clitoris begins to enlarge at puberty. “Penis-at-12” phenomenon (due to increase in testosterone levels)

A

5-alpha reductase deficiency

30
Q

Treatment for pyruvate dehydrogenase deficiency

A

Ketogenic diet (high in fats)

31
Q

Phenoxybenzamine: non-selective alpha-blocker used in the treatment of

A

Pheochromocytoma

32
Q

Sicca Syndrome or Sicca Complex

A

Describes dryness of exocrine glands, particularly of the eyes and the mouth, in the absence of an autoimmune disease

33
Q

Sjogren-Larsson (AR)

A

Congenital ichthyosis (dry and scaly, fishlike skin)
Intellectual disability
Spastic paraplegia
Mutation of fatty aldehyde dehydrogenase gene on chromosome 17p

34
Q

Mirtazapine

A

Antidepressive and sedative properties to treat patient’s depression and insomnia

35
Q

PID triad

A

Fever, Abdominal pain, vaginal discharge

Note: if Right upper quadrant pain Think Fitz-Hugh-Curtis syndrome

36
Q

Hepatitis A antibodies

A

4-week intubation period
IgM = diagnostic
IgG= elevated indefinitely after exposure (used for previous exposure)

37
Q

Left supraclavicular lymph node (Virchow’s node)

A

Metastatic stomach cancer

B/c thoracic duct drains all structures on the left of the thoracic cavity and all structures below the diaphragm

38
Q

Enfuvirtide

A

Interferes w/ gp41-mediated fusion of HIV into cells

39
Q

Multiple injuries, short stature, progressive hearing loss, blue sclera

A

Osteogenesis Imperfecta

40
Q

Ethics

A

Ask open ended questions…. then provide empathetic and knowledgeable answers

41
Q

Most common tumor in women (especially black women)?

A

Leiomyoma

GnRH agonist and surgical removal = Tx

42
Q

Aminoglycosides require what?

A

Oxygen (ex: gentamicin)

43
Q

In Homocystinuria which amino acid becomes essential

A

Cysteine lol….(tyrosine becomes essential in PKU)

Note: lens subluxation and kyphosis

44
Q

Positive nitroprusside cyanide test

A

Homocystinuria (AR)

45
Q

IgG against Rh+

A

Attack on fetal RBCs Hydrops fetalis

46
Q

Lymph drainage of RIGHT chest, back, arm, neck and head

A

Right lymphatic duct

47
Q

Type III familial dyslipidemia

A

Dysbetalipoproteinemia (altered production of apolipoprotein E)
Increased LDL and VLDL and total cholesterol levels

48
Q

Gram negative reportable infection in all 50 states

A

Gonorrhea

49
Q

EBV associations

A

Mono
Oral hairy leukoplakia (HIV)
Hodgkin and non-Hodkins (lymphoproliferative disorders in immunocompromised)
Note:
there is an associated HIV Burkitt and a sporadic

50
Q

CD5 (+) NHL (t(11;14)) translocation

A

Mantle Cell: overexpression of cyclin D1 proto-oncogene

Imhotep 2 (9 decks)

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