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MT6327 > 2S [LEC]: Other Blood Groups > Flashcards

2S [LEC]: Other Blood Groups Flashcards

1
Q

Blood groups most significant in transfusion practice

A

ABO, Rh

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2
Q

One or more antigens produced by alleles at a single gene locus or at loci so closely linked that crossing over does not occur or is very rare

A

Blood group system

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3
Q

This type of RBCs can be very helpful when evaluating antibodies to unknown high-prevalence antigens

A

Null phenotype RBCs

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4
Q

A description of which antigens are present on an individual’s RBCs and simply indicates the results of serologic tests on those RBCs

A

Phenotype

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5
Q

Composed of the actual genes that an individual has inherited and can be determined only by family or DNA studies

A

Genotype

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6
Q

According to ISBT, this is defined as “consisting of one or more antigens controlled at a single gene locus, or by two or more very closely linked homologous genes with little or no observable recombination between them”

A

Blood group system

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7
Q

These are antigens that have a biochemical, serologic, or genetic relationship but do not meet the criteria for a system

A

Collections

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8
Q

Antigens classified as a collection are assigned a ___ number

A

200

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9
Q

All remaining RBC antigens that are not associated with a system or a collection are catalogued into the ___ series of low-prevalence antigens, or the ___ series of high-prevalence antigens

A

700
901

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10
Q

A unique blood group system as it is not synthesized by the RBCs but are from plasma adsorbed onto RBC membrane

A

Lewis

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11
Q

The Le gene is located on which chromosome?

A

Chromosome 19

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12
Q

Which gene enables the H gene transferase to act in the secretions in that case of Lewis blood group?

A

Se gene

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13
Q

ISBT number of the Lewis blood group

A

007

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14
Q

Genes present in the Lewis blood group system that do not produce detectable products

A

le, h, se (amorph genes)

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15
Q

If Le gene is inherited, which antigens are found in the secretions and adsorbed onto the red cell?

A

Lea

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16
Q

If Se gene is inherited, which antigens are found in the secretions and adsorbed onto the red cell?

A

Leb

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17
Q

The Le gene codes for an enzyme which add what sugar to type 1 chains?

A

L-fucose

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18
Q

Which gene/s is/are needed for the expression of Lea substance?

A

Le gene

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19
Q

Which gene/s is/are needed for the expression of Leb substance?

A

Le & Se genes

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20
Q

Lewis phenotype that is discovered to be mostly non-secretors of ABH substances

A

Le(a+b-)

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21
Q

Lewis phenotype that is discovered to be mostly secretors of ABH substances

A

Le(a-b+)

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22
Q

Lewis phenotype that is discovered to be either secretors or non-secretors of ABH substances

A

Le(a-b-)

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23
Q

Lewis phenotype that is the result of the genetic interaction of Lele and Sese genes

A

Le(a-b+)

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24
Q

In the case of Le(a-b+) phenotype, both Lea-soluble and Leb-soluble antigens can be found in the secretion, but only which antigen adsorbs onto the red cell?

A

Leb

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25
The process of removing antibody from the serum
Absorption
26
The uptake of antibody or antigen by a cell
Adsorption
26
The process of removing antibody from an antigen
Elution
27
A blood group not intrinsic to the red cell, but is rather synthesized by the C4 complement protein
Chido/Rodgers
28
Also referred as the "plasma antigen"
Lewis antigen
29
Lewis antigen found in non-secretors
Lea
30
Lewis phenotype found in newborn
Le(a-b-)
31
Structural composition of Lewis antigen found in plasma
Glycolipids
32
Structural composition of Lewis antigen found in the secretions
Glycoproteins
33
Individuals with Le(a-b-) phenotype are how many percent secretors?
80%
34
Individuals with Le(a-b-) phenotype are how many percent non-secretors?
20%
35
Identify the substance/s present in the secretion based on the inherited genes: Le, Se, A/B/H
Leb, ABH
36
Identify the substance/s present in the secretion based on the inherited genes: lele, Se, A/B/H
ABH
37
Identify the substance/s present in the secretion based on the inherited genes: Le, sese, A/B/H
None
38
Identify the substance/s present in the secretion based on the inherited genes: lele, sese, A/B/H
None
39
Identify the substance/s present in the secretion based on the inherited genes: Le, sese, hh, A/B
None
40
Identify the substance/s present in the red cell antigens based on the inherited genes: Le, Se, A/B/H
ABH, Leb
41
Identify the substance/s present in the red cell antigens based on the inherited genes: lele, Se, A/B/H
ABH
42
Identify the substance/s present in the red cell antigens based on the inherited genes: Le, sese, A/B/H
Lea
43
Identify the substance/s present in the red cell antigens based on the inherited genes: lele, sese, A/B/H
ABH
44
Identify the substance/s present in the red cell antigens based on the inherited genes: Le, sese, hh, A/B
None
45
A Lewis phenotype that arises from the inheritance of an Le, Se, and H gene
Le(a-b+)
46
How many blood group systems are there in total?
47
47
Antibody most associated with Lewis blood group system
IgM
48
T/F: Lewis antigens are often associated with cases of HDFN and HTR
False
49
Lewis antibody most commonly encountered
Anti-Lea
50
Lewis antibody with reported HTR reactions
Anti-Lea
51
T/F: Since the Lewis blood group is associated with IgM, all antibodies from it would only react at room temperature
False (Anti-Lea may also react at 37C)
52
Lewis glycolipids are not detectable in the plasma until about how many days after birth?
10 days
53
The true Lewis phenotype
Le(a-b+)
54
Blood group system associated with urea transport
Kidd Blood Group
55
T/F: Anti-Jka and anti-Jkb is commonly associated with severe HDFN
False (Kidd is rarely associated with severe HDFN)
56
Blood group system commonly associated with delayed fatal hemolytic transfusion reaction
Kidd Blood Group
57
Blood group system associated that can act as chemokines
Duffy Blood Group
58
Blood group system that is a known receptor for malarial infection
Duffy Blood Group
59
The Duffy Blood Group is a notorious receptor for which Plasmodium species?
P. vivax P. knowlesi
60
First blood group system to be discovered using AHG test
Kell Blood Group
61
3rd most immunogenic antigen
K (Kell)
62
Protein requirement for the Kell antigen to be expressed
Kx
63
Low prevalence antigen from the Kell blood group
K (Kell)
64
High prevalence antigen from the Kell blood group
k (Cellano)
65
Most commonly identified immunogenic antigen aside from AB and D antigen
Kell
66
Lack of Kx antigen results to what phenotype?
McLeod phenotype
67
Blood group associated with CGD
Kell Blood Group
68
Blood group associated with Hodgkin Lymphoma
Lewis Blood Group
69
The McLeod phenotype is associated with what specific condition?
Chronic Granulomatous Disease (CGD)
70
Blood group associated with Mongoloid ancestry
Diego Blood Group
71
The M and the N antigens are both located at the glycophorin A, but are differentiated by ___
1st and 5th amino acid
72
The universal antigen is found in which antigen?
Ss
73
The S and s antigens are located at which glycophorin?
Glycophorin B
74
Blood group antigen that is a receptor of P. falciparum
MN
75
Anti-N best reacts at what pH?
6.5
76
Anti-M is associated with what antibody type?
IgM
77
Blood group antibody seen in hemodialysis patients
Anti-N (Anti-N f)
78
Type of hemolysis commonly caused by HTR from Kidd antibodies
Extravascular
79
Amino acid located at position 1 of M antigen
Serine
80
Amino acid located at position 1 of N antigen
Leucine
81
Amino acid located at position 5 of M antigen
Glycine
81
Amino acid located at position 5 of N antigen
Glutamic acid
82
The Jk locus is located on what chromosome?
Chromosome 18
83
Antibody type associated with Kidd
IgG
84
Effect of enzymes on the Kidd antigens
Enhanced
85
Autoantibodies with specificity to which antigens are associated with Autoimmune Hemolytic Anemia?
Kidd
86
ISBT number designated to Duffy blood group system
008
87
Duffy phenotype that has a high incidence among Blacks
Fy(a-b-)
88
The difference between Fya and Fyb lies on which position of amino acid?
42nd
89
At position 42, Fya has which amino acid?
Glycine
90
At position 42, Fyb has which amino acid?
Aspartic acid
91
Type of hemolysis commonly caused by HTR from Duffy antibodies
Extravascular
92
In detecting Duffy antibodies, which method is commonly used?
Indirect Antihuman Globulin Test
93
ISBT number designated to Kell blood group
006
94
ISBT number designated to Kx blood group
019
95
The genetic loci of the Kell antigen is located at what chromosome?
Chromosome 7
96
ISBT number designated to the MNS system
002
97
The MNS genes are located on which chromosome?
Chromosome 4
98
At position 29, the S antigen has which amino acid?
Methionine
99
At position 29, the s antigen has which amino acid?
Threonine
100
Important markers in paternity studies
MNS antigens
101
Are MNS antigens found on the red cells, or in body fluids and secretions?
On red cells
102
Blood antibody that is associated with formaldehyde sterilization of machine
Anti-N
103
Anti-S, and anti-s are associated with which antibody class?
IgG
104
ISBT number designated to P1
003
105
ISBT number designated to P
028
106
Blood group antigens assigned to the Globoside collection
Pk and LKE
107
Antigen that serves as the receptor for parvovirus B19
P antigen
108
Antigen receptor for shiga toxins and E. coli-associated HUS
Pk antigen
109
Antibody class associated with Anti-P1
IgM
110
Blood group system antigens that serves as receptors for P-fimbriated uropathogenic E. coli
P system antigens
111
Blood group antigen that may provide some protection against HIV infection of peripheral blood mononuclear cells
Pk
112
This antibody can be neutralized with a soluble substance found in hydatid cyst fluid
Anti-P1
113
Individuals infected with fascioliasis (bovine liver fluke disease) have strong reaction indicative of which antibodies?
Anti-P1
114
Antibody that is clinically significant and is associated with spontaneous abortions in rare cases
Alloanti-P
115
Antibody that is clinically significant, hemolytic, and is associated with spontaneous abortions
Anti-PP1Pk (Tja)
116
Specificity to this antibody is associated with cold-reactive IgG autoantibody in patients with paroxysmal nocturnal hemoglobinuria
Autoanti-P
117
Antibody that undergoes biphasic hemolysis
Autoanti-P
118
ISBT number designated to the I system
027
119
Patients with M. pneumoniae infection may develop strong cold agglutinins with specificity to which antigen?
I antigen (autoanti-I specificity)
120
Two populations where benign IgM anti-IT was frequently found
Melanesians Yanomami Indians in Venezuela
121
Antibody associated with infectious mononucleosis
Anti-i
122
The genetic loci of the Rh and Duffy antigens are located at what chromosome?
Chromosome 1
123
The genetic loci of the I antigen is located at what chromosome?
Chromosome 6
124
The genetic loci of the ABO antigens are located at what chromosome?
Chromosome 9
125
The genetic loci of the P1 antigen is located at what chromosome?
Chromosome 22
126
Other human blood group system associated with Decay Accelerating Factor (DAF)
Cromer
127
Other human blood group system associated with ADP-ribosyltransferase 4
Dombrock
128
Other human blood group system produced in glycophorin C and D
Gerbich
129
Other human blood group system associated with CD44
Indian
130
Other human blood group system associated with Erythroblast membrane-associated protein
Scianna
131
Other human blood group system found on the protein acetylcholinesterase
Cartwright
132
Allele from the Kidd blood group that encodes for Jka and Jk3 antigens and is codominant with Jkb allele
Jka allele
133
Allele from the Kidd blood group that encodes for Jkb and Jk3 antigens and is codominant with Jka allele
Jkb allele
134
A silent allele from the Kidd blood group that produces neither Jka nor Jkb
Jk allele
135
Allele from the Kidd blood group that is common among Polynesians, Filipinos, and Chinese populations
Jk allele
136
T/F: Kidd antibodies are difficult to detect in the lab as it tends to disappear over time
True
137
In what part of the cell are the Kell antigens found?
Glycoprotein of the integral part of the rbc membrane
138
Most common non-ABO antibody after anti-D
Anti-K
139
T/F: The McLeod phenotype affects only female with decreased Kell system antigen expression
False (males)
140
Antigens in this blood group are structurally related to ABH antigens and exist as glycoproteins and glycolipids
P antigens
141
__-like substance was identified in Ascaris suum and Lumbricoides terrestis
P1
142
Blood group associated with H. pylori infection
Lewis

MT6327 (8 decks)

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