25: Benign Neoplasms - Abbott Flashcards
review normal skin structure
- round, flat, coin like, waxy plaques that vary in diameter from mm to several cm
- with OR without pigment
seborrheic keratoses
tx: not unless bothersome
rare before 30
Leser-Trelat Sign ***
sudden onset of numerous SKs may indicate an nderlying visceral malignancy
morphology of fibroepitheliail polyp-acrochordron
fibrovascular core covered by benign squamous epithelium
most common epithelial cysts
epidermal inclusion cyst (epidermoid cyst)
single subcutaneosu nodule at birth on lateral aspect of upper eyelid
dermoid cyst
caused by mutation in keratin 17
steatocystoma
- commonly in sternal, axillae, groin
multiple trichilemmoma is associated with …
cowden’s disease
- AD mution of PTEN
- high risk breast and thyroid carcinomas
- oral lesions, acral keratoses, macrocephaly
solitary firm nodule on head > upper limbs > neck > trunk
pilomatrixoma
- most commonly cheek
Birt-Hogg-Dube Syndrome is associated with…
internal disease
- benign and malignant renal tumors; spontaneous pneumothorax
- due to mutation to gene encoding prtn folliculin
- observe multiple fibrofolliculomas, trichodiscomas, and acrochordons
describe nevus sebaceous
- Also called organoid nevus
- Not a melanocytic proliferation
- Often presents at birth, M=F
- Presents on head/neck, particularly scalp
- Benign, but secondary tumors can arise within [ BCC, benign syringocystadenoma papilliferum and trichoblastoma }
yellowish dome shaped papules misdiagnosed as BCC
sebaceous hyperplasia
- found on face of older adults
can be seen in Muit-Torre Syndrome
- AD inherited defect in DNA mismatch repair gene
sebaceous adenoma and sebaceoma
- face and scalp of older people
cutaneous and visceral findings for MTS
- sebaceous tumors
- colon CA
- can do immunostaining for mismatch repair enzymes (look for MSH2 gone)
cylindroma is associated with ….
(head an neck, pink/red nodule)
brooke-spiegler syndrome
