13: Autoimmune and HIV - Feilmeier Flashcards
are autoimmune diseases secondary to tissue damage?
NO - clinical or experimental evidence that such a reaction is not secondary to tissue damage but is of primary pathogenetic significance
what is dermatomyositis?
inflammatory m disease, resulting from immune-mediated intramuscular vessel injury
- common present with proximal m weakness
gottron’s sign or papules
- smooth, flat-topped, violaceous to red lesions on knuckles
- ** pathognomonic for dermatomyositis
dermal lesions dermatomyositis
- helitrope erythema of the eyelids
- gottron’s sign or papules
- photosensitive
- poikiloderma
rheumatoid arthritis produces a proliferative __________ at the joints
synovitis
key cutaneous manifestation rheumatoid arthritis
subcutaneous nodules
- usually present over joints and may or may not be symptomativ
CREST syndrome
calcinosis raynaud phenomenon esophageal dysmotility sclerodactyly telangiectasia
what is scleroderma/systemic sclerosis
excessive deposition of collagen/fibrosis secondary to abnormal activation of the immmune system due to unknown causes
dermal manifestations of scleroderma
generalized - raynauds, pufffiness/edema, narrow fingers and toes
localized - central thickened ivory with peripheral hyperpigmentation, hair loss, anhydrosis
linear - band like induration that might cause contracture
Sm antigen and antibodies against double stranded DNA
systemic lupus erythema SLE
butterfly rash
SLE
what do you see in nails of SLE patient
nail folds typically show telangiectasis
+ nikolsky sign
- ability to produce a blister by rubbing skin adjacent to a natural blister
- indicates pemphigus group
pemphigus group blistering diseases (superficial)
+ nikolsky sign
+ acantholysis ( loss of intercellular connections, such as desmosomes, resulting in loss of cohesion b/w keratinocytes)
- nikolsky sign
pemphigoid group blistering disease (separation at basement membrane level)
