23_Signal Transduction I Flashcards
Which type of cell signalling requires cells to be in contact? (i.e. both the ligand and the receptor are membrane-bound)
juxtacrine
What is the difference between autocrine and paracrine signalling?
autocrine: receptor for signal is on same cell (signalling cell = target cell)
paracrine: receptor for signal is on same cell type
How are endorcrine signals carried through the body?
via bloodstream
Which types of receptor based signalling involve a secreted stimulus?
(choose from juxto/auto/para/endocrine)
autocrine, paracrine, endocrine
What is an example of a gas that can act as an extracellular messenger?
NO, CO2
What are sterols derived from? How about eiconsanoids?
sterols: cholesterol
eicosanoids: arachidonic acid
By definition, second messengers are (proteins/non-protein).
non-protein
Does the human genome encode more phosphatases or kinases?
kinases
> 500 kinases; >100 phosphatases
(Kinases/phosphatases) dephosphorylate their substrate.
phosphatases
In reversible phosphorylation, where does the phosphoryl group added to a substrate protein come from?
ATP
Kinases transfer phosphoryl groups to which amino acid residues on substrate proteins?
Thr, His, Tyr, Arg, Ser
“So You Think He’s Right?”
Which gland is prolactin secreted from?
pituitary
What does an activated Jak2 phosphorylate?
itself, the receptor, and STAT
What domain on STAT allows it to interact with a phosphorylated Y?
SH2
What must happen to STAT before it can dimerize?
it needs to be phosphorylated
