12_Location, Location, Location Flashcards
Where is ceramide converted into complex sphingolipids?
Golgi
On which end of the protein MUST the signal sequence lie for proteins imported into mitochondria and chloroplasts?
amino
What is the signal sequence for import into peroxisomes? Which end of the protein is it on?
SKL-COOH
Do peroxisomes have their own DNA?
no
What are peroxisomes?
Membrane-bound organelles containing oxidative enzymes
What do the enzymes in peroxisomes oxidize? What is formed?
Oxidize long-chain fatty acids to synthesize plasmalogens
What toxic compound is formed as a by-product in peroxisomes? How is it broken down?
H2O2; broken down by catalase
What signal mediates uptake of proteins into peroxisomes?
PTS (peroxisomal targeting signal)
What sequence on proteins can target them for uptake into mitochondria? Chloroplasts?
M: presequence
C: transit peptide
For proteins to be uptaken into mitochondria, they must be (folded/unfolded).
unfolded
What type of protein is Hsp70?
chaperone
What does a protein interact with in the outer mitochondrial membrane?
TOM complex
What cleaves the presequence once a protein is uptaken into a mitochondrion?
MPP (mitochondrial processing peptidase)
Which phopholipids are abundant in the IMM?
CL and PG
Which TIM complex do proteins that will be embedded into the IMM interact with?
TIM 22
