19_Cell-cell interactions

Question 1

Which cell-cell interactions are calcium-dependent?

Answer 1

cadherin-cadherin and selectin-lectin interactions

Question 2

Which type of intercellular interactions help establish spatial order in embryogenesis?

Answer 2

cadherin-cadherin interactions

Question 3

How is spatial order established in embrogenesis?

Answer 3

Cells from different germ layers have distinct adhesive properties. These selective cell affinities help establish spacial order of different tissues within the embryo through cadherin-cadherin interactions.

Question 4

What do IgSF proteins interact with in cell-cell adhesion?

Answer 4

other IGSF members OR integrins

Question 5

Which class of adhesion proteins do ICAMs belong to?

Answer 5

IgSF

Question 6

What is an example of an IgSF important to neural development?

Answer 6

L1

Question 7

What are ICAMs in blood vessels called?

Answer 7

VCAMs

Question 8

What are the domains of IgSF proteins?

Answer 8

Fn (Fibronectin) III & Ig

Question 9

What class of proteins act as receptors for ICAMs?

Answer 9

Integrins

Question 10

What types of selectins are present on endothelial cells?

Answer 10

E- and P-selection

Question 11

What cell-cell interaction protein is initially upregulated in endothelial cells in response to inflammation?

Answer 11

selectin

Question 12

What is the function of IL-8 in neutrophil trapping?

Answer 12

activates G-protein coupled receptors on neutrophil => activates integrins on neutrophil