21_Cell Junctions II

Question 1

Which cell-cell junctions form the paracellular pathway?

Answer 1

tight junctions

Question 2

Disorders involving thin hair, retinal degradation and limb malformation are a result of mutations in which cell adhesion protein?

Answer 2

cadherin

Question 3

What are symptoms of plakophilin mutations?

Answer 3

kinky hair and fragile skin

Question 4

Where is keratin 14 expressed? What are the consequences of weak keratin 14?

Answer 4

basal cell layer of epidermis

blister in same layer; fragile skin

Question 5

What type of cells make up most of the lens?

Answer 5

Fibre cells

Question 6

How do gap junction connexins maintain lens transparency?

Answer 6

GJs to other cells maintain ion flow and promote crystallin cytoplasmic protein function & structure

Question 7

What is a ocular consequence of gap junction mutations?

Answer 7

cloudy lens

Question 8

What is the cause of Bullous pemphigoid? Symptoms?

Answer 8

autoantibodies against hemidesmosome proteins result in loss of adhesion below the basal cell layer of the dermis.

Sx: blistering