2.2.4. Dermatopathology Lab

Question 1

Eczematous Dermatitis

Answer 1

Heterogenous group of pruritic inflammatory disorders

Question 2

Etiology of Eczematous Dematitis

Answer 2

1. Infection
2. Chemicals (contact dermatitis)
3. Atopy (allergy)

Question 3

Type IV cell-mediated Eczematous dermatitis

Answer 3

Chemicals act as antigens, resulting from cooperation of skin macrophages (Langerhans cells) and helper T lymphocytes

Question 4

Morphologic findings of Eczematous dermatitis

Answer 4

Acute stage: spongiosis (intercellular edema) with vesicle formation

Chronic stage: acanthosis, hyperkeratosis, and lichenification

Question 5

Neurodermatitis (lichen simplex chronicus)

Answer 5

This lesion is clinically indistinguishable from chronic eczematous dermatitis. It produces anatomic changes entirely secondary to scratching (the cause of the pruritus is unknown but may be psychogenic)

Question 6

Psoriatic arthritis

Answer 6

Severe destructive rheumatoid arthritis-like lesions that commonly affect the fingers (associated with Psoriasis that has autoimmune etiology)

Question 7

Hyperkeratosis

Answer 7

Increased thickness of the stratum corneum

Question 8

Parakeratosis

Answer 8

Hyperkeratosis with retention of nuclei of keratinocytes

Question 9

Spongiosis

Answer 9

Epidermal intercellular edema with widening of intercellular space

Question 10

Acanthosis

Answer 10

Thickening of the epidermis

Question 11

Acantholysis

Answer 11

Separation of epidermal cells, one from the other; cells appear to float within extracellular space

Question 12

Lichenification

Answer 12

Accentuation of skin markings caused by scratching

Question 13

Acrochordon

Answer 13

AKA fibroepithelial polyp, skin tag

Extremely common lesion that occurs most often on the face near the eyelids, neck, trunk, or axilla. It consists of a central connective tissue core covered by stratified squamous epithelium